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Genetic analysis of erythromycin production in Streptomyces erythreus
Demonstration of the occurrence of natural genetic recombination during conjugal mating in S. erythreus enabled comparison of the genetic linkage relationships of three different ery mutations with seven other markers on a simple chromosome map.
Isolation of isoflavones from soy-based fermentations of the erythromycin-producing bacterium Saccharopolyspora erythraea
- P. Hessler, P. E. Larsen, A. Constantinou, K. Schram, J. Weber
- BiologyApplied Microbiology and Biotechnology
- 1 April 1997
Results from this study indicate that genistin (the glucoside form of Genistein), which is added to the fermentation in the soybean media, was converted to genistein through the action of a β-glucosidase produced by the organism.
An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea.
A recombinant mutant of the erythromycin-producing bacterium, Saccharopolyspora eryTHraea, produced an erystromycin derivative, 6-deoxyerythromcin A, that could not be obtained readily by chemical synthesis.
Organization of a cluster of erythromycin genes in Saccharopolyspora erythraea
- J. Weber, J. Leung, G. Maine, R. Potenz, T. Paulus, J. DeWitt
- Biology, ChemistryJournal of bacteriology
- 1 May 1990
The new Ery phenotype, EryH, was marked by the accumulation of the intermediate 6-deoxyerythronolide B (DEB), suggesting a defect in the operation of the C-6 hydroxylase system, and a block in the synthesis or addition reactions for the first sugar group.
Engineering precursor flow for increased erythromycin production in Aeromicrobium erythreum.
Cloning of genes involved in erythromycin biosynthesis from Saccharopolyspora erythraea using a novel actinomycete-Escherichia coli cosmid.
Engineering of the methylmalonyl-CoA metabolite node of Saccharopolyspora erythraea for increased erythromycin production.
Effects of methylmalonyl-CoA mutase gene knockouts on erythromycin production in carbohydrate-based and oil-based fermentations of Saccharopolyspora erythraea
- A. Reeves, I. Brikun, William H. Cernota, B. Leach, Melissa C. Gonzalez, J. Weber
- BiologyJournal of Industrial Microbiology and…
- 21 February 2006
A metabolic model is proposed where in carbohydrate-based fermentations MCM acts as a drain on the methylmalonyl-CoA metabolite pool, and in oil- based fermentations,MCM acts in the reverse direction to fill the methyl malonyl -CoA pool.
The use of a chromosome integration vector to map erythromycin resistance and production genes in Saccharopolyspora erythraea (Streptomyces erythraeus).
A Chromosome Integration System for Stable Gene Transfer into Thermus flavus
- J. Weber, Scot P. Johnson, V. Vonstein, M. Casadaban, D. Demirjian
- 1 March 1995
A chromosomal integration system for gene transfer into the extreme thermophile Thermus flavus relies on integration at the site of leuB (3-isopropylmalate dehydrogenase) which was cloned from T. flavus.