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Prospects for hepatitis C virus therapeutics: levovirin and viramidine as improved derivatives of ribavirin.
- J. Watson
- Current opinion in investigational drugs
- 1 May 2002
Ribavirin, in combination with interferons, has proved clinically useful for the treatment of hepatitis C virus (HCV) infection despite uncertainty as to its true mechanism of action. Its… Expand
A Novel, Highly Selective Inhibitor of Pestivirus Replication That Targets the Viral RNA-Dependent RNA Polymerase
ABSTRACT We report on the highly potent and selective antipestivirus activity of 5-[(4-bromophenyl)methyl]-2-phenyl-5H-imidazo[4,5-c]pyridine (BPIP). The 50% effective concentration (EC50) for… Expand
Unruly Bodies: Autoethnography and Authorization in Nafissatou Diallo's 'De Tilene au Plataeu (A Dakar Childhood)
- J. Watson
Cette analyse du De Tilene au Plateau de Diallo considere ce texte a la lumiere des efforts de l'ecrivain pour detruire les frontieres qui existent entre les ecritures autobiographiques et… Expand
Characterization of a novel antibacterial agent that inhibits bacterial translation.
Bacterial protein synthesis is the target for several classes of established antibiotics. This report describes the characterization of a novel translation inhibitor produced by the soil bacterium… Expand
Hepatitis C virus RNA quantitation and degradation studies in whole blood samples in vitro
Hepatitis C virus (HCV) qualitative and quantitative polymerase chain reaction (PCR) tests have evolved from specialist research tools into tests that are widely used in routine clinical practice.… Expand
SAR studies on dihydropyrimidinone antibiotics.
- L. Xu, L. Zhang, +12 authors C. U. Kim
- Medicine, Chemistry
- Bioorganic & medicinal chemistry letters
- 15 March 2011
There is an urgent need for the development of novel antimicrobial agents that offer effective treatment against MRSA. Using a new class of dipeptide antibiotic TAN-1057A/B as lead, we designed,… Expand
The chromosomes of monotreme mammals
Morphometric and molecular analysis of two distinct forms of Pseudocrossidium crinitum
- J. Watson
Two distinct forms of Pseudocrossidium crinitum (Bryophyta) exista form with a white hair point on the leaf, and one with a yellow hair point on the leaf. The white and yellow forms exist in similar… Expand
Viral RNA-Dependent RNA Polymerase Pestivirus Replication That Targets the A Novel , Highly Selective Inhibitor of
2006, 80(1):149. DOI: 10.1128/JVI.80.1.149-160.2006. J. Virol. Johan Neyts Julia Watson, Erik De Clercq, Gerhard Puerstinger and Koenen, Pierre Kerkhofs, Ruben O. Donis, Piet Herdewijn, Carine… Expand