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GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding
Significance The mechanism by which vertebrate animals control their body weight is a complex process involving a variety of molecules that regulate feeding and metabolism. Some of these moleculesExpand
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ProSAAS-Derived Peptides are Colocalized with Neuropeptide Y and Function as Neuropeptides in the Regulation of Food Intake
ProSAAS is the precursor of a number of peptides that have been proposed to function as neuropeptides. Because proSAAS mRNA is highly expressed in the arcuate nucleus of the hypothalamus, we examinedExpand
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Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake
Stimulation of the receptor GPR171 with a small-molecule ligand results in hyperphagia and weight gain in mice. Discovering chemicals that control appetite Understanding the signals that controlExpand
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Quantitative Peptidomics of Purkinje Cell Degeneration Mice
Cytosolic carboxypeptidase 1 (CCP1) is a metallopeptidase that removes C-terminal and side-chain glutamates from tubulin. The Purkinje cell degeneration (pcd) mouse lacks CCP1 due to a mutation.Expand
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Opioid Receptor Function Is Regulated by Post-endocytic Peptide Processing*
Background: Endothelin-converting enzyme-2 (ECE2) localizes to early endosomes and processes neuropeptides at non-classical sites at acidic pH. Results: Inhibiting ECE2 activity impairs recycling andExpand
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Evidence of oxidative stress and mitochondrial dysfunction in spinocerebellar ataxia type 2 (SCA2) patient fibroblasts: Effect of coenzyme Q10 supplementation on these parameters.
Spinocerebellar ataxia type 2 (SCA2) is a rare neurodegenerative disorder caused by a CAG repeat expansion in the ataxin-2 gene. We show increased oxidative stress, abnormalities in the antioxidantExpand
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Enhancement of Autophagy and Solubilization of Ataxin-2 Alleviate Apoptosis in Spinocerebellar Ataxia Type 2 Patient Cells
Spinocerebellar ataxia type 2 (SCA2), a rare polyglutamine neurodegenerative disorder caused by a CAG repeat expansion in the ataxin-2 gene, exhibits common cellular phenotypes with otherExpand
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Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics
J. Neurochem. (2010) 114, 215–225.
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Quantitative peptidomics of mice lacking peptide-processing enzymes.
Peptidomics is defined as the analysis of peptides present in a tissue extract, usually using mass spectrometry-based approaches. Unlike radioimmunoassay-based detection techniques, peptidomicsExpand
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Quantitative peptidomics to measure neuropeptide levels in animal models relevant to psychiatric disorders.
Neuropeptides play many important roles in cell-cell signaling and are involved in the control of anxiety, depression, pain, reward pathways, and many other processes that are relevant to psychiatricExpand
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