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The microRNA miR-124 suppresses seizure activity and regulates CREB1 activity
  • W. Wang, X. Wang, +10 authors J. Luo
  • Medicine, Biology
  • Expert Reviews in Molecular Medicine
  • 21 March 2016
miR-124, a brain-specific microRNA, was originally considered as a key regulator in neuronal differentiation and the development of the nervous system. Here we showed that miR-124 expression wasExpand
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Pro-survival and anti-inflammatory roles of NF-κB c-Rel in the Parkinson's disease models
The pathological hallmarks of Parkinson's disease (PD) are the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) and the presence of overactivated glial cellsExpand
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Brain-specific NRSF deficiency aggravates dopaminergic neurodegeneration and impairs neurogenesis in the MPTP mouse model of Parkinson’s disease
Degeneration of the dopaminergic neurons in the substantia nigra and the resultant dopamine depletion from the striatum are the hallmarks of Parkinson’s disease (PD) and are responsible for theExpand
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Gating TrkB switch by methylglyoxal enables GLO1 as a target for depression
Major depressive disorder (MDD) is a severe psychiatric illness that affects about 16 percent of the global population. Despite massive efforts, unravelling the pathophysiology of MDD and developingExpand
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Methylglyoxal modification of TrkB promotes synaptic plasticity and enhances resilience to chronic stress
  • Z. Wu, Yingxue Fu, +22 authors Yonghua Wang
  • Chemistry, Biology
  • 12 November 2018
The endogenous metabolite methylglyoxal (MGO) has recently emerged as a potential mediator of psychiatric disorders, such as anxiety and depression, but its precise mechanism of action remains poorlyExpand
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Inflammation associated with chronic heart failure leads to enhanced susceptibility to depression
Epidemiological and clinicopathological studies indicate that there is a high risk for chronic heart failure (CHF) in patients suffering from neuropsychiatric disorders, such as depression. However,Expand
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RESP18 deficiency has protective effects in dopaminergic neurons in an MPTP mouse model of Parkinson's disease
ABSTRACT Regulated endocrine‐specific protein, 18 kDa (RESP18) was first cloned in 1994. Its function in the brain especially in neurodegenerative diseases remains unclear. In this study, RESP18Expand
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Isolation of circulating tumor cells and detection of EGFR mutations in patients with non-small-cell lung cancer
The aim of the present study was to develop a procedure for the isolation of circulating tumor cells (CTCs), and to evaluate its application in the detection of epidermal growth factor receptorExpand
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Unilateral vertical retraction syndrome with orbital band.
Vertical retraction is a special form of retraction syndrome. In the past, the cause of this retraction has been thought to be a limiting fibrous band at the level of the inferior rectus muscleExpand
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