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A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition.
TLDR
A double-negative feedback loop controlling ZEB1-SIP1 and miR-200 family expression that regulates cellular phenotype is established and has direct relevance to the role of these factors in tumor progression. Expand
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
TLDR
It is reported that FUNDC1, an integral mitochondrial outer-membrane protein, is a receptor for hypoxia-induced mitophagy, and its findings offer insights into mitochondrial quality control in mammalian cells. Expand
Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction*
TLDR
The predicted attenuation ofβ-amyloid content in the brain during CR can be reproduced in mouse neurons in vitro by manipulating cellular SIRT1 expression/activity through mechanisms involving the regulation of the serine/threonine Rho kinase ROCK1. Expand
Regression of castrate-recurrent prostate cancer by a small-molecule inhibitor of the amino-terminus domain of the androgen receptor.
TLDR
This work identifies EPI-001, a small molecule that blocked transactivation of the NTD and was specific for inhibition of AR without attenuating transcriptional activities of related steroid receptors. Expand
Diet‐induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease
TLDR
It is found that diet‐induced insulin resistance promoted amyloidogenic β‐amyloid (Aβ) A β1–40 and Aβ1–42 peptide generation in the brain that corresponded with increased γ‐secretase activities and decreased insulin degrading enzyme (IDE) activities. Expand
Integrated Profiling of MicroRNAs and mRNAs: MicroRNAs Located on Xq27.3 Associate with Clear Cell Renal Cell Carcinoma
TLDR
The results indicate that the phenotypic status of ccRCC is characterized by a loss of normal renal function, downregulation of metabolic genes, and upregulation of many signal transduction genes in key pathways. Expand
Role of ABL family kinases in cancer: from leukaemia to solid tumours
TLDR
Enhanced ABL expression and activation in some solid tumours, together with altered cell polarity, invasion or growth induced by activated ABL kinases, suggest that drugs targeting these kinases may be useful for treating selectedSolid tumours. Expand
Insulin-like growth factor-1 sustains stem cell mediated renal repair.
TLDR
It is indicated that MSC exert beneficial effects on tubular cell repair in acute kidney injury by producing the mitogenic and pro-survival factor IGF-1. Expand
Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex.
TLDR
It is concluded that beta-cell lmx-1 functions by binding to the FLAT element and interacting through the LIM-containing amino terminus with shPan-1 bound at the Far element, forming the minimal components for a functional minienhancer complex. Expand
The Noncoding RNA Expression Profile and the Effect of lncRNA AK126698 on Cisplatin Resistance in Non-Small-Cell Lung Cancer Cell
TLDR
Cisplatin resistance in non-small-cell lung cancer cells may relate to the changes in noncoding RNAs as identified by microarray expression profiling of mRNAs, lncRNA and miRNA in A549 cells and cisplatin resistant A549/CDDP cells. Expand
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