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The Nuclear Factor of Activated T Cells (Nfat) Transcription Factor Nfatp (Nfatc2) Is a Repressor of Chondrogenesis
Nuclear factor of activated T cells (NFAT) transcription factors regulate gene expression in lymphocytes and control cardiac valve formation. Here, we report that NFATp regulates chondrogenesis inExpand
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Lack of Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2, China
A woman with coronavirus disease in her 35th week of pregnancy delivered an infant by cesarean section in a negative-pressure operating room. The infant was negative for severe acute respiratoryExpand
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Pathogenetic mechanisms of posttraumatic osteoarthritis: opportunities for early intervention.
Osteoarthritis (OA) is characterized by joint pain and stiffness with radiographic evidence of joint space narrowing, osteophytes, and subchondral bone sclerosis. Posttraumatic OA (PTOA) arises fromExpand
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Absence of transcription factor c-maf causes abnormal terminal differentiation of hypertrophic chondrocytes during endochondral bone development.
In this study, we report that the transcription factor c-Maf is required for normal chondrocyte differentiation during endochondral bone development. c-maf is expressed in hypertrophic chondrocytesExpand
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Bone sialoprotein and osteopontin in bone metastasis of osteotropic cancers.
The mechanisms underlying malignant cell metastasis to secondary sites such as bone are complex and no doubt multifactorial. Members of the small integrin-binding ligand N-linked glycoproteinsExpand
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Transcription factor Nfat1 deficiency causes osteoarthritis through dysfunction of adult articular chondrocytes
Osteoarthritis (OA) is the most common form of joint disease in middle‐aged and older individuals. Previous studies have shown that over‐expression of matrix‐degrading proteinases and proinflammatoryExpand
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Cell-based articular cartilage repair: the link between development and regeneration.
Clinical efforts to repair damaged articular cartilage (AC) currently face major obstacles due to limited intrinsic repair capacity of the tissue and unsuccessful biological interventions. ThisExpand
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Joint Instability and Osteoarthritis
Joint instability creates a clinical and economic burden in the health care system. Injuries and disorders that directly damage the joint structure or lead to joint instability are highly associatedExpand
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Expression and Synthesis of Bone Morphogenetic Proteins by Osteoclasts: A Possible Path to Anabolic Bone Remodeling
Skeletal remodeling is a finely orchestrated process coupling bone formation to bone resorption. The dynamics of coupling is regulated by the microenvironment at the bone remodeling site, which inExpand
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Osteomyelitis: Recent advances in pathophysiology and therapeutic strategies.
This review article summarizes the recent advances in pathogenic mechanisms and novel therapeutic strategies for osteomyelitis, covering both periprosthetic joint infections and fracture-associatedExpand
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