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The Nuclear Factor of Activated T Cells (Nfat) Transcription Factor Nfatp (Nfatc2) Is a Repressor of Chondrogenesis
- A. M. Ranger, L. Gerstenfeld, +5 authors L. Glimcher
- Medicine, Biology
- The Journal of experimental medicine
- 3 January 2000
Nuclear factor of activated T cells (NFAT) transcription factors regulate gene expression in lymphocytes and control cardiac valve formation. Here, we report that NFATp regulates chondrogenesis in… Expand
Lack of Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2, China
A woman with coronavirus disease in her 35th week of pregnancy delivered an infant by cesarean section in a negative-pressure operating room. The infant was negative for severe acute respiratory… Expand
Pathogenetic mechanisms of posttraumatic osteoarthritis: opportunities for early intervention.
Osteoarthritis (OA) is characterized by joint pain and stiffness with radiographic evidence of joint space narrowing, osteophytes, and subchondral bone sclerosis. Posttraumatic OA (PTOA) arises from… Expand
Absence of transcription factor c-maf causes abnormal terminal differentiation of hypertrophic chondrocytes during endochondral bone development.
- H. Maclean, J. Kim, M. Glimcher, J. Wang, H. Kronenberg, L. Glimcher
- Biology, Medicine
- Developmental biology
- 1 October 2003
In this study, we report that the transcription factor c-Maf is required for normal chondrocyte differentiation during endochondral bone development. c-maf is expressed in hypertrophic chondrocytes… Expand
Bone sialoprotein and osteopontin in bone metastasis of osteotropic cancers.
- T. Kruger, A. Miller, A. Godwin, J. Wang
- Biology, Medicine
- Critical reviews in oncology/hematology
- 1 February 2014
The mechanisms underlying malignant cell metastasis to secondary sites such as bone are complex and no doubt multifactorial. Members of the small integrin-binding ligand N-linked glycoproteins… Expand
Transcription factor Nfat1 deficiency causes osteoarthritis through dysfunction of adult articular chondrocytes
- J. Wang, B. M. Gardner, +7 authors H. C. Anderson
- Biology, Medicine
- The Journal of pathology
- 1 October 2009
Osteoarthritis (OA) is the most common form of joint disease in middle‐aged and older individuals. Previous studies have shown that over‐expression of matrix‐degrading proteinases and proinflammatory… Expand
Cell-based articular cartilage repair: the link between development and regeneration.
Clinical efforts to repair damaged articular cartilage (AC) currently face major obstacles due to limited intrinsic repair capacity of the tissue and unsuccessful biological interventions. This… Expand
Joint Instability and Osteoarthritis
- Darryl Blalock, A. Miller, M. Tilley, J. Wang
- Clinical medicine insights. Arthritis and…
- 1 January 2015
Joint instability creates a clinical and economic burden in the health care system. Injuries and disorders that directly damage the joint structure or lead to joint instability are highly associated… Expand
Expression and Synthesis of Bone Morphogenetic Proteins by Osteoclasts: A Possible Path to Anabolic Bone Remodeling
- R. Garimella, Sarah E. Tague, +6 authors H. C. Anderson
- Chemistry, Medicine
- The journal of histochemistry and cytochemistry…
- 3 March 2008
Skeletal remodeling is a finely orchestrated process coupling bone formation to bone resorption. The dynamics of coupling is regulated by the microenvironment at the bone remodeling site, which in… Expand
Osteomyelitis: Recent advances in pathophysiology and therapeutic strategies.
This review article summarizes the recent advances in pathogenic mechanisms and novel therapeutic strategies for osteomyelitis, covering both periprosthetic joint infections and fracture-associated… Expand