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An Isoform of the Neuronal Cyclin-dependent Kinase 5 (Cdk5) Activator (*)
A distinct clone encoding a 39-kDa isoform of Nck5a shares many common characteristics with p35, including Ckd5 activating activity and brain- and neuron-specific expression, suggesting that they define a new family of cyclin-dependent kinase-activating proteins. Expand
Purification and characterization of a novel proline-directed protein kinase from bovine brain.
The brain kinase did not co-purify with a subunit having a molecular weight corresponding to known cyclins, nor did it undergo specific interaction with p13suc1 beads, suggesting that this enzyme is distinct from p34cdc2. Expand
Removal of lead from aqueous solutions by Penicillium biomass.
The removal of lead ions from aqueous solutions by adsorption on nonliving Penicillium chrysogenum biomass was studied and sorption preference for metals decreased in the following order: Pb > Cd > Cu > Zn > As. Expand
Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2.
The results suggest that the brain kinase represents a new category of the cdc2 family, and that some members of thecdc2 kinase family may have major functions unrelated to cell cycle control. Expand
Neuronal Cdc2-like Kinase (Nclk) Binds and Phosphorylates the Retinoblastoma Protein*
It is reported that neuronal Cdc2-like kinase (Nclk), composed of Cdk5 and a neuronal Cdk 5 activator (p25nck5a), can bind and phosphorylate RB in vitro and in vivo, infer that Nclk may play an important role in regulating the activity of RB in the brain, including perhaps in apoptosing neurons. Expand
Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments.
Analysis of tau protein isolated from Alzheimer's paired helical filaments and phosphopeptides isolated from the tryptic digest of the phosphorylated bovine tau suggests that BPDK may be one of the kinases responsible for the abnormal phosphorylation-associated PHF-tau. Expand
A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1.
The 3.0-A structure of a 190-residue fragment of intercellular adhesion molecule-1 (ICAM-1, CD54) reveals two tandem Ig-superfamily (IgSF) domains suited to resist tensile forces during adhesive interactions. Expand
Stimulation of bovine cardiac sarcoplasmic reticulum Ca2+ pump and blocking of phospholamban phosphorylation and dephosphorylation by a phospholamban monoclonal antibody.
  • T. Suzuki, J. Wang
  • Medicine, Biology
  • The Journal of biological chemistry
  • 25 May 1986
A monoclonal antibody was produced against sodium dodecyl sulfate-polyacrylamide gel electrophoresis purified canine phospholamban and isolated from mouse ascites by chromatography on a hydroxylapatite column and it may be suggested that the antigenic site of A1 antibody is proximal to the phosphorylation sites of phosphol amban. Expand
Regulation of calcineurin by metal ions. Mechanism of activation by Ni2+ and an enhanced response to Ca2+/calmodulin.
  • C. Pallen, J. Wang
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • 25 May 1984
It is found that Ni2+ is the best activator of calcineurin both in the presence and absence of calmodulin, and there is evidence to suggest a competition for binding to the enzyme. Expand
Substrate specificity characterization of a cdc2-like protein kinase purified from bovine brain.
HeLa cell p34CDc2 kinase displays similar specificity to that of the bovine cdc2-like kinase, as the additional determinants outside of the consensus motif that contribute to the efficient phosphorylation of the histone peptide by this novel enzyme also appear to be important for p34cdc2-catalyzed phosphorylations. Expand