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The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
Cancer chemotherapeutic agents such as cisplatin exert their cytotoxic effect by inducing DNA damage and activating programmed cell death (apoptosis). The tumour-suppressor protein p53 is anExpand
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Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation
Ataxia telangiectasia (AT) is a rare human autosomal recessive disorder with pleiotropic phenotypes, including neuronal degeneration, immune dysfunction, premature ageing and increased cancer risk.Expand
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Global control of cell-cycle transcription by coupled CDK and network oscillators
A significant fraction of the Saccharomyces cerevisiae genome is transcribed periodically during the cell division cycle, indicating that properly timed gene expression is important for regulatingExpand
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The p53/p63/p73 family of transcription factors: overlapping and distinct functions.
The p53 gene is the most frequently mutated gene in human cancer. The identification of two homologues, p63 and p73, revealed that p53 is a member of a family of related transcription factors. GivenExpand
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  • Open Access
Three distinct signalling responses by murine fibroblasts to genotoxic stress
GENOTOXIC stress triggers signalling pathways that mediate either the protection or killing of affected cells. Whereas induction of p53 involves events in the cell nucleus1, the activation ofExpand
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Degradation of Retinoblastoma Protein in Tumor Necrosis Factor- and CD95-induced Cell Death*
The product of the retinoblastoma susceptibility gene, RB, is a negative regulator of cell proliferation. Inactivation of RB does not interfere with embryonic growth or differentiation. However,Expand
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Regulation of cell death by the Abl tyrosine kinase
  • J. Wang
  • Biology, Medicine
  • Oncogene
  • 20 November 2000
The c-abl proto-oncogene encodes a protein tyrosine kinase that is distributed in the nucleus and the cytoplasm of proliferating cells. In the nucleus, c-Abl activity is negatively regulated by theExpand
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Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases
The F-actin cytoskeleton is a fundamental component of all eukaryotic cells. It provides force and stability and plays an integral role in a diverse array of cellular processes. The spatiotemporalExpand
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  • Open Access
TRAF Family Proteins Interact with the Common Neurotrophin Receptor and Modulate Apoptosis Induction*
The common neurotrophin receptor, p75NTR, has been shown to signal in the absence of Trk tyrosine kinase receptors, including induction of neural apoptosis and activation of NF-κB. However, theExpand
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Cellular responses to DNA damage.
  • J. Wang
  • Medicine, Biology
  • Current opinion in cell biology
  • 1 April 1998
The exposure of cells to DNA damage inducers triggers a wide range of cellular responses including an alteration in gene expression, a delay in cell-cycle progression and the stimulation of DNAExpand
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