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PGE2 differentially regulates monocyte-derived dendritic cell cytokine responses depending on receptor usage (EP2/EP4).
Dendritic cells (DCs) are central players in coordinating immune responses, both innate and adaptive. While the role of lipid mediators in the immune response has been the subject of manyExpand
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The pharmacology and therapeutic relevance of endocannabinoid derived cyclo-oxygenase (COX)-2 products.
The discovery of anandamide and 2-arachidonyl glycerol (2-AG) as naturally occurring mammalian endocannabinoids has had important and wide-reaching therapeutic implications. This, to a large extent,Expand
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Identification and pharmacological characterization of the prostaglandin FP receptor and FP receptor variant complexes
Background and purpose: A prostamide analogue, bimatoprost, has been shown to be effective in reducing intraocular pressure, but its precise mechanism of action remains unclear. Hence, to elucidateExpand
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Immobilization of glucose oxidase on chitosan–SiO2 gel
Abstract Novel porous gels of chitosan–SiO2 were prepared by coupling chitosan with tetramethoxy silicane through the sol–gel approach at ambient conditions. The characteristics of the gel wereExpand
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Bimatoprost, prostamide activity, and conventional drainage.
PURPOSE Despite structural similarity with prostaglandin F(2 alpha), the ocular hypotensive agent bimatoprost (Lumigan; Allergan, Inc., Irvine, CA) shows unique pharmacology in vitro and functionalExpand
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Roles of affinity and lipophilicity in the slow kinetics of prostanoid receptor antagonists on isolated smooth muscle preparations
BACKGROUND AND PURPOSE The highly lipophilic acyl‐sulphonamides L‐798106 and L‐826266 showed surprisingly slow antagonism of the prostanoid EP3 receptor system in guinea‐pig aorta. Roles of affinityExpand
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Differential effects of prostaglandin E2-sensitive receptors on contractility of human ocular cells that regulate conventional outflow.
PURPOSE The goal of this study was to functionally compare prostaglandin E2 (PGE2)-sensitive receptors in human primary cells involved in conventional outflow. METHODS The expression profile ofExpand
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Identification of an antagonist that selectively blocks the activity of prostamides (prostaglandin‐ethanolamides) in the feline iris
The prostamides (prostaglandin‐ethanolamides) and prostaglandin (PG) glyceryl esters are biosynthesized by COX‐2 from the respective endocannabinoids anandamide and 2‐arachidonyl glycerol. AgonistExpand
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Gene profiling involved in immature CD4+ T lymphocyte responsible for systemic lupus erythematosus.
We attempted to characterize the genes expression of CD4+ T lymphocytes for the pathogenesis of systemic lupus erythematosus (SLE). Genomewide gene expression profiles of CD4+ T cells, which wereExpand
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Cellular basis for bimatoprost effects on human conventional outflow.
PURPOSE Bimatoprost is a widely used ocular hypotensive agent to treat glaucoma. It lowers intraocular pressure in humans by increasing both pressure-independent (uveoscleral) and pressure-dependentExpand
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