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Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow.
HSC homing, quiescence, and self-renewal depend on the bone marrow HSC niche. A large proportion of solid tumor metastases are bone metastases, known to usurp HSC homing pathways to establishExpand
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Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells.
Early B lymphopoiesis in mammals is induced within the bone marrow (BM) microenvironment, but which cells constitute this niche is not known. Previous studies had shown that osteoblasts (OBs) supportExpand
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Neural Cache: Bit-Serial In-Cache Acceleration of Deep Neural Networks
  • C. Eckert, X. Wang, +5 authors R. Das
  • Computer Science
  • ACM/IEEE 45th Annual International Symposium on…
  • 9 May 2018
This paper presents the Neural Cache architecture, which re-purposes cache structures to transform them into massively parallel compute units capable of running inferences for Deep Neural Networks.Expand
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Annexin II/Annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer
One of the most life‐threatening complications of prostate cancer is skeletal metastasis. In order to develop treatment for metastasis, it is important to understand its molecular mechanisms. OurExpand
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Erythropoietin Couples Hematopoiesis with Bone Formation
Background It is well established that bleeding activates the hematopoietic system to regenerate the loss of mature blood elements. We have shown that hematopoietic stem cells (HSCs) isolated fromExpand
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Expression of CXCR4 and CXCL12 (SDF‐1) in human prostate cancers (PCa) in vivo
Human prostate cancers (PCa) express great variability in their ability to metastasize to bone. The identification of molecules associated with aggressive phenotypes will help to define PCa subsetsExpand
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Dopamine Receptor mRNA Expression in Human Striatum and Neocortex
The distributions of the transcripts encoding the five dopamine receptors have been determined in the human striatum and selected regions of the neocortex. In the striatum significant levels ofExpand
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Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantation.
Differentiation of hematopoietic stem cells (HSCs) after birth is largely restricted to the bone marrow cavity, where HSCs are associated closely with osteoblasts (OBs). How OBs localize HSCs to theExpand
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Erythropoietin mediated bone formation is regulated by mTOR signaling
The role of erythropoietin (Epo) and Epo/Epo receptor (EpoR) signaling pathways for production of red blood cells are well established. However, little is known about Epo/EpoR signaling inExpand
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GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche.
Our recent studies have shown that annexin II, expressed on the cell surface of osteoblasts, plays an important role in the adhesion of hematopoietic stem cells (HSCs) to the endosteal niche.Expand
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