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A human gut microbial gene catalogue established by metagenomic sequencing
TLDR
The Illumina-based metagenomic sequencing, assembly and characterization of 3.3 million non-redundant microbial genes, derived from 576.7 gigabases of sequence, from faecal samples of 124 European individuals are described, indicating that the entire cohort harbours between 1,000 and 1,150 prevalent bacterial species and each individual at least 160 such species. Expand
A metagenome-wide association study of gut microbiota in type 2 diabetes
TLDR
MGWAS analysis showed that patients with type 2 diabetes were characterized by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in various opportunistic pathogens, as well as an enrichment of other microbial functions conferring sulphate reduction and oxidative stress resistance. Expand
The oyster genome reveals stress adaptation and complexity of shell formation
TLDR
The sequencing and assembly of the oyster genome using short reads and a fosmid-pooling strategy and transcriptomes of development and stress response and the proteome of the shell are reported, showing that shell formation in molluscs is more complex than currently understood and involves extensive participation of cells and their exosomes. Expand
The tomato genome sequence provides insights into fleshy fruit evolution
TLDR
A high-quality genome sequence of domesticated tomato is presented, a draft sequence of its closest wild relative, Solanum pimpinellifolium, is compared, and the two tomato genomes are compared to each other and to the potato genome. Expand
Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
TLDR
A draft genome sequence of the red jungle fowl, Gallus gallus, provides a new perspective on vertebrate genome evolution, while also improving the annotation of mammalian genomes. Expand
Richness of human gut microbiome correlates with metabolic markers
TLDR
The authors' classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities. Expand
Genome sequence and analysis of the tuber crop potato
TLDR
The potato genome sequence provides a platform for genetic improvement of this vital crop and predicts 39,031 protein-coding genes and presents evidence for at least two genome duplication events indicative of a palaeopolyploid origin. Expand
The sequence and de novo assembly of the giant panda genome
TLDR
Using next-generation sequencing technology alone, a draft sequence of the giant panda genome is generated and assembled, indicating that its bamboo diet might be more dependent on its gut microbiome than its own genetic composition. Expand
The sequence and de novo assembly of the giant panda genome
TLDR
This corrects the article to show that the Higgs boson genome is a “spatially aggregating ‘spatiotemporal ’ organisation’, rather than a ‘cell-based’ organisation, which is more closely related to the immune system. Expand
Aegilops tauschii draft genome sequence reveals a gene repertoire for wheat adaptation
TLDR
This draft genome sequence provides insight into the environmental adaptation of bread wheat and can aid in defining the large and complicated genomes of wheat species. Expand
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