Functional connectivity of human striatum: a resting state FMRI study.
This work provides a comprehensive functional connectivity analysis of basal ganglia circuitry in humans through a functional magnetic resonance imaging examination during rest and revealed subtler distinctions within striatal subregions not previously appreciated by task-based imaging approaches.
Varieties of Attention-Deficit/Hyperactivity Disorder-Related Intra-Individual Variability
Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.
- B. S. Bunney, J. Walters, R. Roth, G. Aghajanian
- Biology, PsychologyJournal of Pharmacology and Experimental…
- 1 June 1973
Neostriatal 3,4-dihydroxyphenylacetic acid was inceased by chlorpromazine, decreaed by amphetamine and unchanged by promethazine, thus paralleling the effects of these drugs on dopaminergic unit activity, compatible with the neuronal feedback hypothesis.
Dopaminergic Neurons Intrinsic to the Primate Striatum
The results demonstrate that the dopaminergic cell population of the striatum responds to dopamine denervation by increasing in number, apparently to compensate for loss of extrinsic dopaminaergic innervation.
Phase relationships support a role for coordinated activity in the indirect pathway in organizing slow oscillations in basal ganglia output after loss of dopamine
State-Dependent Spike and Local Field Synchronization between Motor Cortex and Substantia Nigra in Hemiparkinsonian Rats
High coherence between LFP oscillations in cortex and SNpr supports the view that cortical activity facilitates entrainment and synchronization of activity in basal ganglia after loss of dopamine, but dramatic increases in cortical power and relative timing of phase-locked spiking in these areas suggest that additional processes help shape the frequency-specific tuning of the basal Ganglia–thalamocortical network during ongoing motor activity.
The Response of Subthalamic Nucleus Neurons to Dopamine Receptor Stimulation in a Rodent Model of Parkinson’s Disease
- D. S. Kreiss, C. Mastropietro, S. S. Rawji, J. Walters
- Biology, PsychologyJournal of Neuroscience
- 1 September 1997
The premise that therapeutic efficacy in the treatment of Parkinson’s disease is associated with a decrease in the activity of the STN is supported, but assumptions about the roles of D1 and D2 receptors in the regulation of neuronal activity ofThe STN in both the intact and dopamine-depleted states are challenged.
Multisecond oscillations in firing rate in the basal ganglia: robust modulation by dopamine receptor activation and anesthesia.
- D. N. Ruskin, D. A. Bergstrom, Y. Kaneoke, B. N. Patel, M. Twery, J. Walters
- BiologyJournal of Neurophysiology
- 1 May 1999
The modulation of multisecond periodicities in firing rate by dopaminergic agonists suggests the involvement of these patterns in behaviors and cognitive processes that are affected by dopamine.
Unilateral lesion of the nigrostriatal pathway decreases the firing rate and alters the firing pattern of globus pallidus neurons in the rat
Data from this study suggest that, in locally anesthetized animals, the removal of the tonic dopaminergic input to the basal ganglia causes pallidal cells to decrease their firing rates in a time‐dependent fashion and causes reversable firing pattern changes.