Share This Author
From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs.
The first complete portrait of this underground market is presented along with the relevant legal, technological, and scientific developments which have driven its evolution.
Pharmacological Investigations of the Dissociative ‘Legal Highs’ Diphenidine, Methoxphenidine and Analogues
The results suggest that these 1,2-diarylethylamines are relatively selective NMDAR antagonists with weak off-target inhibitory effects on dopamine and norepinephrine reuptake.
Return of the lysergamides. Part IV: Analytical and pharmacological characterization of lysergic acid morpholide (LSM-775).
Findings suggest that 5-HT1A activation by L SM-775 masks its ability to induce the head twitch response, which is potentially consistent with reports in the literature indicating that LSM-775 is only capable of producing weak LSD-like effects in humans.
Return of the lysergamides. Part I: Analytical and behavioural characterization of 1-propionyl-d-lysergic acid diethylamide (1P-LSD).
It is found that 1P-LSD produced a dose-dependent increase in HTR counts, and that it had ~38% of the potency of LSD, consistent with its classification as a serotonergic hallucinogen.
Return of the lysergamides. Part II: Analytical and behavioural characterization of N6 -allyl-6-norlysergic acid diethylamide (AL-LAD) and (2'S,4'S)-lysergic acid 2,4-dimethylazetidide (LSZ).
Analytical characterization of powdered AL-LAD and LSZ tartrate samples and their semi-quantitative determination on blotter paper is reported to assist research communities that are interested in various aspects related to substance use and forensic identification.
Preparation and characterization of the 'research chemical' diphenidine, its pyrrolidine analogue, and their 2,2-diphenylethyl isomers.
1,2- diphenylethylamines appears to reflect the exploration of alternatives to arylcyclohexylamine-type substances, such as methoxetamine, PCP and PCPy-based analogues that also show NMDA receptor activity as demonstrated here for diphenidine.
Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species
First reported fatalities associated with the 'research chemical' 2-methoxydiphenidine.
- S. Elliott, S. Brandt, J. Wallach, Hamilton Morris, P. Kavanagh
- ChemistryJournal of analytical toxicology
- 1 May 2015
Three deaths which involved the detection of 2-MXP in post-mortem blood and urine were encountered in forensic casework and analytical data is presented to assist analytical toxicologists with future casework.
Test purchase, synthesis, and characterization of 2-methoxydiphenidine (MXP) and differentiation from its meta- and para-substituted isomers.
Analytical data obtained for the three purchased samples were consistent with the synthesized 2-MXP standard and the differentiation between the isomers was possible, and distinct stability differences were observed for all three isomers during in-source collision-induced dissociation of the protonated molecule.
Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs
It is demonstrated that ebselen and ebsulfur analogs are inhibitors of HDACs, supporting further preclinical development of this class of compounds for potential therapeutic applications.