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Revised criteria for diagnosis of coeliac disease
Serum concentrations of tumour necrosis factor alpha in childhood chronic inflammatory bowel disease.
Production of TNF alpha may be associated with growth failure in relapse of colonic inflammatory bowel disease and it may diminish pituitary growth hormone release. Expand
Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease.
It is suggested that this degree of TNF alpha production probably contributes significantly to the pathogenesis of both Crohn's disease and ulcerative colitis, by impairing the integrity of epithelial and endothelial membranes, increasing inflammatory cell recruitment, and by prothrombotic effects on the vascular endothelium. Expand
The genetically programmed down-regulation of lactase in children.
Analysis of 866 children showed evidence that the lactase persistence/nonpersistence polymorphism began before 5 years of age, although the onset and extent are somewhat variable. Expand
- J. Walker-Smith
- Archives of disease in childhood
- 1 May 1978
A 'battle' began, which is not yet completely resolved, of terminology in relation to naming the virus particle, which seems that rotavirus is the most durable name. Expand
Disruption of sulphated glycosaminoglycans in intestinal inflammation
- S. Murch, T. Macdonald, J. Walker-Smith, P. Lionetti, M. Levin, N. Klein
- Medicine, Biology
- The Lancet
- 20 March 1993
It is suggested that inflammatory disruption of vascular and connective tissue GAGs may be an important pathogenetic mechanism, contributing to the leakage of protein and fluid, thrombosis, and tissue remodelling seen in inflammatory bowel disease. Expand
Endoscopic assessment of the colonic response to corticosteroids in children with ulcerative colitis.
- R. M. Beattie, S. Nicholls, P. Domizio, C. Williams, J. Walker-Smith
- Journal of pediatric gastroenterology and…
- 1 May 1996
Twenty children with active ulcerative colitis were assessed before and after 8 weeks of medical therapy with 5-aminosalicylic acid (5-ASA) derivatives and corticosteroids. Local therapy was given… Expand
Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa.
Study of interferon-gamma and interleukin-2 production in the mucosa of children with Crohn's disease or ulcerative colitis and in histologically normal mucosa from patients without inflammatory bowel disease reveals an ongoing cell-mediated immune response inThe mucosa in Crohn’s disease. Expand
Contribution of the MHC region to the familial risk of coeliac disease
- S. Bevan, S. Popat, +24 authors R. Houlston
- Biology, Medicine
- Journal of medical genetics
- 1 September 1999
The MHC genes contribute no more than 40% of the sib familial risk of coeliac disease and the non-HLA linked gene (or genes) are likely to be the stronger determinant of coediac disease susceptibility. Expand
The Frequency of Cells Secreting Interferon-γ and Interleukin-4, -5, and -10 in the Blood and Duodenal Mucosa of Children with Cow's Milk Hypersensitivity
The results show a general enhancement of Th1 and Th2-type cytokine-secreting cells in the blood of children with cow's milk hypersensitivity, although the increased IL-4-secrificial cells in blood in CMA may be of relevance in view of the fact that this disease is IgE-mediated. Expand