Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
- J. Walboomers, M. Jacobs, N. Muñoz
- BiologyJournal of Pathology
- 1 September 1999
The presence of HPV in virtually all cervical cancers implies the highest worldwide attributable fraction so far reported for a specific cause of any major human cancer, and the rationale for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening.
The use of general primers GP5 and GP6 elongated at their 3' ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR.
- A. M. de Roda Husman, J. Walboomers, A. V. D. van den Brule, C. Meijer, P. Snijders
- BiologyJournal of General Virology
- 1 April 1995
The data indicate that the GP5+/6+ PCR method provides an increased detection level mainly of uncommon, apparently poorly matched HPV types in cervical scrapes and most likely in the enlargement of the spectrum of HPVs detectable by this assay.
Distribution of 37 mucosotropic HPV types in women with cytologically normal cervical smears: The age‐related patterns for high‐risk and low‐risk types
- M. Jacobs, J. Walboomers, C. Meijer
- Biology, MedicineInternational Journal of Cancer
- 15 July 2000
It is suggested that screening for abnormal cytology implies screening for HR HPV infections and the subsequent treatment results in a decline of HR HPV prevalence in contrast to LR HPV prevalence during the years of screening.
Relation of human papilloma virus status to cervical lesions and consequences for cervical-cancer screening: a prospective study
- M. Nobbenhuis, J. Walboomers, C. Meijer
- MedicineThe Lancet
- 3 July 1999
[Sexually transmitted infection as a cause of anal cancer].
- M. Frisch, B. Glimelius, M. Melbye
- MedicineUgeskrift for læger
- 6 November 1997
It is concluded that most anal cancers appear to be caused by sexually transmitted types of human papillomaviruses and, consequently, that anal cancer is a potentially preventable neoplasm.
A general primer GP5+/GP6(+)-mediated PCR-enzyme immunoassay method for rapid detection of 14 high-risk and 6 low-risk human papillomavirus genotypes in cervical scrapings
- M. Jacobs, P. Snijders, A. V. D. van den Brule, T. Helmerhorst, C. Meijer, J. Walboomers
- BiologyJournal of Clinical Microbiology
- 1 March 1997
This novel HR/LR HPV PCR-EIA allows accurate and rapid identification of high-risk and low-risk HPV types in cervical scrapings and will facilitate HPV detection in HPV mass-screening programs.
Effect of oral contraceptives on risk of cervical cancer in women with human papillomavirus infection: the IARC multicentric case-control study
- V. Moreno, F. Bosch, S. Franceschi
- MedicineThe Lancet
- 30 March 2002
Determinants for genital human papillomavirus (HPV) infection in 1000 randomly chosen young Danish women with normal Pap smear: are there different risk profiles for oncogenic and nononcogenic HPV…
- S. Kjaer, A. V. D. van den Brule, C. Meijer
- BiologyCancer Epidemiology, Biomarkers and Prevention
- 1 October 1997
This study confirms the venereal nature of HPV infection and hypothesizes that the low-risk HPV infection, which correlates with recent sexual behavior, may be more transient than infection with the oncogenic HPV types, which correlate with lifetime exposure measurements of sexual habits.
Human papillomavirus infection and invasive cervical cancer in Paraguay
- P. A. Rolón, Jennifer S. Smith, J. Walboomers
- Biology, MedicineInternational Journal of Cancer
- 15 February 2000
Results of a further IARC case‐control study conducted in Asunción, Paraguay, to examine the association between specific HPV types and invasive cervical cancer as well as risk factors other than HPV found strong associations were found.
Human papillomavirus and invasive cervical cancer in Brazil.
- J. Eluf-Neto, M. Booth, N. Muñoz, F. X. Bosch, C. Meijer, J. Walboomers
- MedicineBritish Journal of Cancer
- 1 January 1994
Number of sexual partners, early age at first intercourse, parity and duration of oral contraceptive use were significantly associated with an increased risk of cervical cancer and the very high risks found in this study further implicate this virus in the aetiology of cervicalcancer.
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