Experience with the murine local lymph node assay: inability to discriminate between allergens and irritants.
- J. Montelius, H. Wahlkvist, A. Boman, P. Fernström, L. Gråbergs, J. Wahlberg
- BiologyActa Dermato-Venereologica
The local lymph node assay in its present design and with the criteria used for a positive response requires further validation studies and perhaps further development before it can be accepted as an alternative to guinea pig tests for allergenicity.
Monitoring levels of preservative sensitivity in Europe
The current high level of sensitivity to MDBGN requires an urgent safety re‐evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave‐on products.
Guidelines for measurement of cutaneous blood flow by laser Doppler flowmetry
Technical variation, instrument validation including a standard reactive hyperemia experiment, and a standard operating procedure are discussed and included in the guidelines.
Patch testing with fragrances: results of a multicenter study of the European Environmental and Contact Dermatitis Research Group with 48 frequently used constituents of perfumes
The top 25 fragrances commonly found in various products caused few reactions in dermatological patients and these few appeared to be clinically irrelevant, with the possible exeption of Lyral®.
Corticosteroid contact allergy: an EECDRG multicentre study
This article describes the results of an EECDRG multicentre study on contact allergy to corticosteroids, which investigated patients in 13 centres in the course of 1993, and 1000 patients in 1 centre in 1993 and 1994.
Resorption of mercuric chloride and methyl mercury dicyandiamide in guinea-pigs through normal skin and through skin pretreated with acetone, alkylaryl-sulphonate and soap.
Guinea pig maximization test.
A COMPARATIVE INVESTIGATION OF THE PERCUTANEOUS ABSORPTION OF METAL COMPOUNDS IN THE GUINEA PIG BY MEANS OF THE RADIOACTIVE ISOTOPES: 51CR, 58CO, 65ZN, 110MAG, 115MCD, 203HG.
The corn parison of the metal compounds with one another is considered as of primary importance, and for this reason great significance has been attached to the application of a uniform experimental method.
Uptake via the blood and elimination of 10 organic solvents following epicutaneous exposure of anesthetized guinea pigs.
Percutaneous toxicity of metal compounds. A comparative investigation in guinea pigs.
- J. Wahlberg
- MedicineArchives of environmental health
- 1 August 1965