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Monitoring levels of preservative sensitivity in Europe
The current high level of sensitivity to MDBGN requires an urgent safety re‐evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave‐on products. Expand
Experience with the murine local lymph node assay: inability to discriminate between allergens and irritants.
The local lymph node assay in its present design and with the criteria used for a positive response requires further validation studies and perhaps further development before it can be accepted as an alternative to guinea pig tests for allergenicity. Expand
Guidelines for measurement of cutaneous blood flow by laser Doppler flowmetry
Technical variation, instrument validation including a standard reactive hyperemia experiment, and a standard operating procedure are discussed and included in the guidelines. Expand
Patch testing with fragrances: results of a multicenter study of the European Environmental and Contact Dermatitis Research Group with 48 frequently used constituents of perfumes
The top 25 fragrances commonly found in various products caused few reactions in dermatological patients and these few appeared to be clinically irrelevant, with the possible exeption of Lyral®. Expand
Corticosteroid contact allergy: an EECDRG multicentre study
This article describes the results of an EECDRG multicentre study on contact allergy to corticosteroids, which investigated patients in 13 centres in the course of 1993, and 1000 patients in 1 centre in 1993 and 1994. Expand
Guinea pig maximization test.
Uptake via the blood and elimination of 10 organic solvents following epicutaneous exposure of anesthetized guinea pigs.
The elimination curves were nonlinear in all cases and corresponding to a kinetic model involving at least two compartments for benzene, 1,1,2,2-tetrachloroethane, 1-1,1-trichloroethylene, and 1,3,3- trichlorOethylene. Expand
Chromated steel and contact allergy
A simple procedure for the determination of leachable Cr6+ that could be used in industrial applications to check the quality of chromated products and to establish a “threshold limit value” for such products is developed. Expand
Histopathology of skin, liver, and kidney after epicutaneous administration of five industrial solvents to guinea pigs.
The histopathology of the skin, liver, and kidney was studied in guinea pigs after epicutaneous administration of the industrial solvents n-hexane, toluene, carbon tetrachloride, 2-chloroethanol, and n-butyl acetate to cause progressing nuclear pyknosis and junctional separation between the basement membrane and the basal cells. Expand