J. W. Yam
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Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression.
Deleted in liver cancer 1 (DLC1) is a recently identified tumor suppressor gene frequently underexpressed in hepatocellular carcinoma (HCC). DLC1 encodes a Rho GTPase-activating protein domain that… Expand
Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours.
- S. C. Wong, S. F. Lo, K. Lee, J. W. Yam, J. K. Chan, W. L. Wendy Hsiao
- Medicine, Biology
- The Journal of pathology
- 1 February 2002
Frizzled-related protein (Frp) is a new family of secreted proteins that contain a region homologous to the extracellular cysteine-rich domain (CRD) of the frizzled family proteins. The role of Frp… Expand
Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity.
- T. H. Leung, Y. Ching, +4 authors I. Ng
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 18 October 2005
The deleted in liver cancer 2 (DLC2) gene, located at chromosome 13q12.3, is a recently identified tumor suppressor gene. The gene is frequently underexpressed in human hepatocellular carcinoma, and… Expand
ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma
Summary Frequent tumor relapse in hepatocellular carcinoma (HCC) has been commonly attributed to the presence of residual cancer stem cells (CSCs) after conventional treatments. We have previously… Expand
Caveolin-1 overexpression is associated with hepatocellular carcinoma tumourigenesis and metastasis.
Caveolin-1 (Cav1) has been implicated in diverse human cancers, yet its role in hepatocellular carcinoma (HCC) tumourigenesis and metastasis remains elusive. In the current study, we aim to provide a… Expand
Deleted in Liver Cancer 1 (DLC1) Utilizes a Novel Binding Site for Tensin2 PTB Domain Interaction and Is Required for Tumor-Suppressive Function
Background Deleted in liver cancer 1 (DLC1) is a Rho GTPase-activating protein (RhoGAP) frequently deleted and underexpressed in hepatocellular carcinoma (HCC) as well as in other cancers. Recent… Expand
Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma
Tensins are a new family of proteins that act as an important link among extracellular matrix, actin cytoskeleton, and signal transduction and have been implicated in human cancers. Tensin2 was… Expand
Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis.
- F. C. Ko, Lo-Kong Chan, E. Tung, S. Lowe, I. Ng, J. W. Yam
- Medicine, Biology
- 1 October 2010
BACKGROUND & AIMS Deleted in liver cancer 1 (DLC1), which encodes a Rho GTPase activating protein, is a bona fide tumor suppressor in hepatocellular carcinoma. Underexpression of DLC1 in cancer has… Expand
Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein.
The chimeric MLL-EEN fusion protein is created as a result of chromosomal translocation t(11;19)(q23;p13). EEN, an Src homology 3 (SH3) domain-containing protein in the endophilin family, has been… Expand
Mitochondrial targeting of growth suppressor protein DLC2 through the START domain
Deleted in liver cancer 2 (DLC2) is a candidate tumor suppressor frequently found to be deleted in hepatocellular carcinoma. In this study, we determined the subcellular localization of DLC2.… Expand