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The kinetics of triclabendazole disposition in sheep.
To investigate whether the disposition of triclabendazole (TCBZ) and its metabolites in blood or bile influenced its flukicidal potency, TCBZ was administered intraruminally at 10 mg kg-1 to sheep
The disposition of albendazole in sheep.
Albendazole (ABZ) was administered intraruminally to sheep fitted with a permanent bile-duct cannula to determine if its metabolites might contribute to its flukicidal action and it is suggested that ABZ is sequestered in the liver.
Effects of dietary protein intake on responses of young sheep to infection with Trichostrongylus colubriformis.
It was concluded that supplementary feeding with FM substantially reduced the production losses attributable to infection with T. colubriformis and was associated with enhanced expulsion of the parasite burden.
Prolonged administration: A new concept for increasing the spectrum and effectiveness of anthelmintics
The magnitude and duration of concentrations of TBZ, FBZ and OFZ in plasma and other body compartments after administration were compared with their effectiveness against parasites, and the spectrum and effectiveness of benzimidazoles may be improved by extending the period during which parasites are exposed to toxic concentrations.
Comparative pharmacokinetic behaviour of albendazole in sheep and goats.
Albendazole (ABZ) containing a trace of [14C]-ABZ was administered intraruminally at 4.75 mg kg-1 to Merino sheep and Angora goats and the pharmacokinetic behaviour of ABZ and its metabolites in
Contribution of propionate to glucose synthesis in sheep.
Comparisons of the specific radioactivities of plasma glucose and rumen propionate during intraruminal infusions of one of [1-(14)C]-, [2-(14C]], [3-( 14)C]- and [U-(14]C]-propionate indicated considerable exchange of C-1 of Propionate on conversion into glucose.
Disposition of oxfendazole in goats and efficacy compared with sheep.
When given at this rate as a divided dose at 12 hourly intervals over 24 hours, OFZ was significantly more effective than a single dose in reducing egg counts, and a dose rate of 10 mg kg-1 is recommended for goats.
Dietary protein for young grazing sheep: interactions with gastrointestinal parasitism.
It was concluded that supplementary feeding with protein meal substantially reduced production losses attributable to nematode infections in young grazing sheep, due to an enhanced resilience of the host, rather than any major changes in development of protective immunity.
Comparative kinetic disposition of oxfendazole in sheep and goats before and during infection with Haemonchus contortus and Trichostrongylus colubriformis.
It is suggested that goats possess a faster hepatic metabolism than sheep resulting in more rapid elimination of OFZ, and the elimination of plasma [14C] was faster in goats than in sheep.
Comparative pharmacokinetic disposition of closantel in sheep and goats.
Faster elimination resulted in an almost three-fold lowering of AUC in goats and could dramatically reduce the sustained action of closantel in this species compared with sheep.