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In vitro evaluation of azone analogs as dermal penetration enhancers: V. Miscellaneous compounds
Abstract Dermal penetration enhancers were evaluated (14) using diffusion cell techniques, hairless mouse skin and hydrocortisone as the model drug. The following were synthesized:Expand
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Synthesis and antiviral/antitumor evaluation of 2-amino- and 2-carboxamido-3-arylsulfonylthiophenes and related compounds as a new class of diarylsulfones.
Based on general SARs previously described for anti-HIV-1 diarylsulfone derivatives, a series of 2-amino- and 2-carboxamido-3-arylsulfonylthiophenes has been prepared and evaluated as potentialExpand
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Synthesis and cholinergic properties of N-aryl-2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamino analogs of ranitidine.
A series of N-aryl-2-[[[5-[(dimethylamino)methyl]-2- furanyl]methyl]thio]ethylamino analogs of the H2-antagonist, ranitidine, was synthesized and the abilities of the compounds to alleviate theExpand
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A Comparison of the Cholinergic Activity of Selected H2-Antagonists and Sulfoxide Metabolites
Famotidine and selected H2-antagonists were evaluated with respect to toxicity and selected pharmacological activities. When administered intraperitoneally to mice at a dose equivalent to 10 timesExpand
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In vitro evaluation of a series of N-dodecanoyl-L-amino acid methyl esters as dermal penetration enhancers.
A series of N-dodecanoyl-L-amino acid methyl esters (1-10) and n-pentyl N-acetylprolinate (11) were evaluated for dermal enhancement properties using an in vitro diffusion cell technique. Methods ofExpand
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In vitro evaluation of a series of Azone analogs as dermal penetration enhancers. II: (Thio) amides
Abstract The sorption promoting ability of nine Azone ( N -dodecylazacycloheptan-2-one) analogs was tested against the model drug, hydrocortisone 21-acetate using a hairless mouse skin model inExpand
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Azone analogues as penetration enhancers: effect of different vehicles on hydrocortisone acetate skin permeation and retention
Abstract The permeation and skin retention of hydrocortisone-21 -acetate in hairless mouse skin in vitro was examined following topical pretreatment with four novel enhancers in four vehicles:Expand
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Synthesis of 7α-substituted derivatives of 17β-estradiol
Abstract Estrogen receptor (ER) pure antagonists such as ICI-182,780 (fulvestrant) are effective alternatives to tamoxifen (an ER antagonist/weak partial agonist) in the treatment of postmenopausal,Expand
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Ranitidine analog, JWS‐USC‐75IX, enhances memory‐related task performance in rats
The purpose of this study was to evaluate potential cognitive effects and nicotinic receptor binding affinity of a ranitidine analog previously found to antagonize M2 muscarinic‐cholinergic receptorsExpand
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Synthesis of Substituted 2‐Aminopyrrole Analogs of Lidocaine II
The synthesis, local anesthetic, and antiarrhythmic properties of nine 2-diethylaminoacetamido-3-cyano-4-methyl-5-substituted pyrroles are described. All compounds showed local anesthetic activity byExpand
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