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Modularized functions of the Fanconi anemia core complex.
This work reveals the roles of several FA gene products with previously undefined functions and a modularized assembly of the FA core complex. Expand
FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions.
It is found that FANCM and FAAP24 coordinately facilitate FA pathway activation and suppress sister chromatid exchange and nonoverlapping functions such as ATR-mediated checkpoint activation and recombination-independent interstrand crosslink repair. Expand
Proliferating Cell Nuclear Antigen (PCNA)-binding Protein C1orf124 Is a Regulator of Translesion Synthesis*
C1orf124 acts at multiple steps in TLS, stabilizes RAD18 and ubiquitinated PCNA at damage sites, and facilitates the switch from replicative to TLS polymerase to bypass DNA lesion. Expand
Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair
The identification of a unique component of the FA core complex, namely, FAAP20, which contains a RAD18-like ubiquitin-binding zinc-finger domain is reported, which indicates thatFAAP20 is an important player involved in the FA pathway. Expand
Alpha Thalassemia/Mental Retardation Syndrome X-linked Gene Product ATRX Is Required for Proper Replication Restart and Cellular Resistance to Replication Stress*
Somatic knock-out of ATRX displayed perturbed S-phase progression as well as hypersensitivity to replication stress, revealing an unanticipated role of ATrX in maintaining genomic stability upon replication stress. Expand
PHF6 Regulates Cell Cycle Progression by Suppressing Ribosomal RNA Synthesis*
The results reveal that the key function of PHF6 is involved in regulating rRNA synthesis, which may contribute to its roles in cell cycle control, genomic maintenance, and tumor suppression. Expand
PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis
Results reveal that the key function of PHF6 is involved in regulating rRNA synthesis, which may contribute to its roles in cell cycle control, genomic maintenance and tumor suppression. Expand
GABAergic functions and depression: from classical therapies to herbal medicine.
  • J. W. Leung, H. Xue
  • Medicine
  • Current drug targets. CNS and neurological…
  • 1 December 2003
This review addresses recent research on the possible role of GABAergic receptors with regard to depression, and potentially antidepressant phytomedicines acting on this class of receptors. Expand
Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1 promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle cerebral
Taken together, endothelial ET-1 over-expression and ETA receptor activation contributes to the increased oxidative stress, water accumulation and BBB breakdown after transient MCAO leading to more severe neurological deficit and increased infarct. Expand
Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1.
The identification of the PWWP domain-containing protein EXPAND1/MUM1 as an architectural component of the chromatin, which in response to DNA damage serves as an accessory factor to promote cell survival to facilitate proper checkpoint activation and DNA repair is reported. Expand