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Enantioselective Pharmacokinetics of dl-threo-Methylphenidate in Humans
A definitive enantioselective pharmacokinetic evaluation of dl-threo-methylphenidate (MPH) was carried out in 11 healthy volunteers, all of whom received, in a randomized crossover design, three oralExpand
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Evaluation of the Bioequivalence of Highly-Variable Drugs and Drug Products
AbstractPurpose. To establish procedures for the effective evaluation of bioequivalence (BE) for highly-variable drugs and drug products (HVD/P). Methods. 2- and 4-period crossover BE studies with 24Expand
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A placebo-controlled trial of fluoxetine added to neuroleptic in patients with schizophrenia
Following a 2-week placebo lead-in, schizophrenic patients were randomly assigned to fluoxetine 20 mg/day or placebo added to depot neuroleptic for a 6-week, double blind trial. All patients hadExpand
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Pharmacokinetics of chlorpromazine and key metabolites
SummaryA study was carried out in 11 healthy young men to investigate the pharmacokinetics of chlorpromazine (CPZ) after a bolus intravenous (IV) dose (10 mg) and three single oral doses (25, 50 andExpand
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At Issue: Defining Treatment Refractoriness in Schizophrenia
: Addressing the need for research on the nature of refractoriness to antipsychotic drug therapy exhibited by a substantial minority of schizophrenic patients, Philip R.A. May and Sven Jonas DenckerExpand
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Radioimmunoassay for chlorpromazine in plasma.
A radioimmunoassay for chlorpromazine in plasma is described. The antiserum was obtained by immunizing rabbits with a conjugate of bovine serum albumin and N-(2-carboxyethyl)desmethylchlorpromazine.Expand
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The Role of Metabolites in Bioequivalence
The role of metabolites in bioequivalence studies has been a contentious issue for many years. Many papers have published recommendations for the use of metabolite data based on anecdotal evidenceExpand
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The sulfoxidation of fluphenazine in schizophrenic patients maintained on fluphenazine decanoate
Highly sensitive radioimmunoassays were applied to study the sulfoxidation of fluphenazine in 30 schizophrenic patients maintained on either 5 mg or 25 mg fluphenazine decanoate by intramuscularExpand
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Safety, Tolerability, and Effect of Food on the Pharmacokinetics of Iloperidone (HP 873), a Potential Atypical Antipsychotic
Iloperidone (HP 873) is a D2 and 5‐HT2 receptor‐antagonist that is under development as a potential atypical antipsychotic agent. Two studies on iloperidone evaluated its safety and tolerability,Expand
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Studies on the Mechanism of Absorption of Depot Neuroleptics: Fluphenazine Decanoate in Sesame oil
AbstractPurpose. The purpose of the present study was to investigate the pharmacokinetic characteristics of fluphenazine (FLU) and its decanoate (FLU-D) after intravenous and intramuscularExpand
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