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Leptospirosis: a zoonotic disease of global importance.
Determining Risk for Severe Leptospirosis by Molecular Analysis of Environmental Surface Waters for Pathogenic Leptospira
The hypothesis that urban severe leptospirosis in the Peruvian Amazon is associated with higher concentrations of more pathogenic Leptospira at sites of exposure and transmission is supported.
Endemic malaria in the Peruvian Amazon region of Iquitos.
Results indicate that clinical immunity in human populations can be driven in malaria-endemic regions that do not have high intensity malaria transmission and argue for using PCR for epidemiologic investigation and malaria control.
Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes
It is shown here that whole-genome analysis of the parasite can be achieved directly from ex vivo-isolated parasites, without the need for in vitro propagation, and provides a data set for comparative analysis with important potential for identifying markers for global parasite diversity and drug resistance mapping studies.
Plasmodium Ookinete-secreted Proteins Secreted through a Common Micronemal Pathway Are Targets of Blocking Malaria Transmission*
Results support the concept that ookinete micronemal proteins may constitute a general class of malaria transmission-blocking vaccine candidates.
Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax
Signals of natural selection suggest that P. vivax is evolving in response to antimalarial drugs and is adapting to regional differences in the human host and the mosquito vector, highlighting the variable epidemiology of this parasite species.
Diversity of bat-associated Leptospira in the Peruvian Amazon inferred by bayesian phylogenetic analysis of 16S ribosomal DNA sequences.
The role of bats as potential sources of transmission to humans or as maintenance hosts of leptospires is poorly understood. We quantified the prevalence of leptospiral colonization in bats in the
Environmental Exposure and Leptospirosis, Peru
Human exposure to Leptospira in the Iquitos region is high, likely related both to the ubiquity of leptospires in the environment and human behavior conducive to transmission from infected zoonotic sources.
Predictors of lethality in severe leptospirosis in urban Brazil.
Serologic findings with highest titer against Leptospira interrogans serovar Copenhageni did not show significant differences between survivors and non-survivors, and lung involvement was an important predictor of death in leptospirosis in São Paulo, of relevance in lepsis-endemic regions where this complication is common.
Human Leptospirosis Caused by a New, Antigenically Unique Leptospira Associated with a Rattus Species Reservoir in the Peruvian Amazon
A new Leptospira species was isolated from humans with acute febrile illness in the Iquitos region, and it is determined that it is phylogenetically related to, but genetically distinct from, other intermediate Leptonospira such as L. inadai.