• Publications
  • Influence
Microvascular blood flow is altered in patients with sepsis.
Microvascular blood flow alterations are frequent in animal models of sepsis and may impair tissue oxygenation. We hypothesized that alterations of the microcirculation are present in patients withExpand
  • 1,177
  • 53
The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material
PurposeOur objective was to revise the definition of acute respiratory distress syndrome (ARDS) using a conceptual model incorporating reliability and validity, and a novel iterative approach withExpand
  • 746
  • 50
  • PDF
Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock*
Objective:To characterize the time course of microcirculatory alterations and their relation to outcome in patients with septic shock. Design:Prospective, observational study. Setting:Thirty-one-bed,Expand
  • 981
  • 29
Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update
Objective:To provide the American College of Critical Care Medicine with updated guidelines for hemodynamic support of adult patients with sepsis. Data Source:Publications relevant to hemodynamicExpand
  • 495
  • 21
  • PDF
Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study.
BACKGROUND Mortality from severe sepsis and septic shock differs across continents, countries, and regions. We aimed to use data from the Surviving Sepsis Campaign (SSC) to compare models of care andExpand
  • 382
  • 21
The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects*
Objective:To evaluate the effects of dobutamine on microcirculatory blood flow alterations in patients with septic shock. Design:Prospective, open-label study. Setting:A 31-bed, medico-surgicalExpand
  • 413
  • 19
Neutrophil elastase inhibition in acute lung injury: Results of the STRIVE study
Objective:Neutrophil elastase is believed to be an important mediator of acute lung injury. Sivelestat (ONO-5046, Elaspol) is a small molecular weight inhibitor of neutrophil elastase. The primaryExpand
  • 262
  • 16
High tidal volume and positive fluid balance are associated with worse outcome in acute lung injury.
STUDY OBJECTIVES Recent data have suggested that ventilatory strategy could influence outcomes from acute lung injury (ALI) and ARDS. We tested the hypothesis that infection/sepsis and use of higherExpand
  • 365
  • 13
  • PDF
Microvascular alterations in patients with acute severe heart failure and cardiogenic shock.
BACKGROUND Microvascular blood flow alterations may impair tissue oxygenation and may participate in the development of multiple organ failure in patients with severe heart failure. We hypothesizedExpand
  • 366
  • 13
Vasopressor and inotropic support in septic shock: An evidence-based review
Objective:In 2003, critical care and infectious disease experts representing 11 international organizations developed management guidelines for vasopressor and inotropic support in septic shock thatExpand
  • 243
  • 13
  • PDF