• Publications
  • Influence
A new model to assess analgesic activity: Pain‐induced functional impairment in the rat (PIFIR)
A new experimental model to assess analgesic activity of both analgesic and non‐steroidal antiinflammatory drugs in described. It uses the unilateral intra‐articular knee injection of an uric acidExpand
Further evidence that naloxone acts as an inverse opiate agonist: implications for drug dependence and withdrawal.
To test if naloxone behaved as an inverse agonist rather than as an antagonist, its responses in guinea-pig ilea with and without morphine were evaluated and findings can be interpreted in the light of the two-state receptor model. Expand
Acute opioid dependence in the cardiovascular system of the spinal rat.
The results show that the cardiovascular system of the spinal rat is highly sensitive to the abstinence-precipitating actions of NLX after a single dose of morphine, and morphine-free spinal rats gave some abstinence-like responses to NLX, probably because of endogenous release of opioids. Expand
Effects of narcotic analgesics upon the locomotor activity and brain catecholamine content of the mouse.
Tolerance developed to the effects of morphine and related analgesics upon both locomotor activity and brain catecholamine content after the repeated administration of either morphine or levorphanol and pretreatment with naloxone prevented the effects. Expand
Morphine-induced increases in the incorporation of 14 C-Tyrosine into 14 C-Dopamine and 14 C-norepinephrine in the mouse brain: antagonism by naloxone and tolerance.
The present study suggests that the catecholamines may play an important role in the mechanisms by which narcotic analgesics produce certain specific effects. Expand
Operant behavior in the morphine-dependent rhesus monkey.
Drugs producing physical dependence of the morphine type, hut not other classes of drugs, restored both unpunished and punished behavior disrupted by morphine withdrawal. Expand
Effects of indorenate on food intake: a comparison with fenfluramine and amphetamine
The present results suggest the participation of serotoninergic, but not dopaminergic mechanisms, in the decrease in food intake produced by indorenate. Expand
Tolerance to Morphine-Induced Increases in [14C]Catecholamine Synthesis in Mouse Brain
Morphine sulfate increased the incorporation of carbon-14-labeled tyrosine into labeled catecholamines in the mouse brain. Tolerance was manifested by a shift to the right in the dose-response curveExpand
A comparison of the effects of d-amphetamine and morphine upon the locomotor activity of mice treated with drugs which alter brain catecholamine content.
The study suggests that certain effects of morphine are mediated by the release of catecholamines from adrenergic neurons in the brain as well as mechanisms different from those which mediate the effects of d -amphetamine. Expand
Changes in Operant Behavior During Deprivation- and Antagonist-Induced Withdrawal States
It has been shown that in animals with a history of morphine administration changes in behavior produced by antagonists may be found under conditions where overt deprivation-induced withdrawal changes are not demonstrable. Expand