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Immune response in mice that lack the interferon-gamma receptor.
Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor. Expand
Construction and initial characterization of a mouse-human chimeric anti-TNF antibody.
The chimeric A2 antibody (cA2) exhibits better binding and neutralizing characteristics than the murine A2 which was shown to contain a mixture of two kappa light chains, and suggest that it will have advantages over existing murine anti-TNF antibodies for clinical use. Expand
Involvement of the IRF-1 transcription factor in antiviral responses to interferons.
The IRF-1-/- mice were less resistant than normal mice to EMCV infection, as revealed by accelerated mortality and a larger virus titer in target organs, and the absence of IRf-1 did not clearly affect replication of two other types of viruses. Expand
A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44
The data indicate that the inflammatory cytokine (TNF or IL-1)-inducible, secretory TSG-6 protein is a novel member of the family of hyaluronate binding proteins, possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis. Expand
IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice.
The inhibitory action of IL-6 on TNF production is consistent with a predominantly antiinflammatory role ofIL-6 in the intact organism and may represent the negative arm of a regulatory circuit. Expand
Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities.
Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence.
It is concluded that TNF and IL-1 apparently activate IL-6 gene expression by closely related mechanisms involving activation of a NF-kappa B-like factor, whereas the pathway of IL- 6 induction by forskolin is, in part, different. Expand
Interleukin 6: a multifunctional cytokine regulating immune reactions and the acute phase protein response.
The terms “interleukin” or “lymphokine” are now being used for cytokines that can be produced by a variety of cell types and that can affect the functions of many nonhematopoietic cells. Expand
Critical role of a common transcription factor, IRF‐1, in the regulation of IFN‐beta and IFN‐inducible genes.
- L. F. Reis, H. Harada, J. Wolchok, T. Taniguchi, J. Vilcek
- Biology, Medicine
- The EMBO journal
- 1 January 1992
The data show that IRF‐1 is essential for the induced expression of the IFN‐beta gene, and indicate an important role of IRf‐1 in the expression ofIFN‐inducible genes and suggest a role for IRF•1 in many other cytokine actions. Expand
Cytokine-induced gene expression at the crossroads of innate immunity, inflammation and fertility: TSG-6 and PTX3/TSG-14.
Two cytokine-inducible gene products, important in inflammation and infection, also play essential roles in female fertility and female mice with a targeted disruption of either the TSG-6 or PTX3 gene show severe defects in fertility. Expand