• Publications
  • Influence
Immune response in mice that lack the interferon-gamma receptor.
Interferon-gamma (IFN-gamma) exerts pleiotropic effects, including antiviral activity, stimulation of macrophages and natural killer cells, and increased expression of major histocompatibilityExpand
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Construction and initial characterization of a mouse-human chimeric anti-TNF antibody.
Tumor necrosis factor-alpha (TNF) has been implicated in the pathogenesis of a variety of human diseases including septic shock, cachexia, graft-versus-host disease and several autoimmune diseases.Expand
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Involvement of the IRF-1 transcription factor in antiviral responses to interferons.
The mechanisms underlying interferon (IFN)-induced antiviral states are not well understood. Interferon regulatory factor-1 (IRF-1) is an IFN-inducible transcriptional activator, whereas IRF-2Expand
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IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice.
Incubation of the human U937 histiocytic lymphoma cell line with granulocyte-macrophage colony stimulating factor (GM-CSF) rendered the cells responsive to induction of TNF by LPS. Treatment withExpand
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Interleukin 6: a multifunctional cytokine regulating immune reactions and the acute phase protein response.
  • J. Le, J. Vilček
  • Biology, Medicine
  • Laboratory investigation; a journal of technical…
  • 1989
Cytokines are protein mediators of cell-to-cell communication important in a variety of physiologic and pathophysiologic processes. Only a decade ago information about cytokines was limited to theExpand
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Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence.
Using variable-length deletion constructs of the 5'-flanking region of the human interleukin-6 (IL-6) gene linked to the chloramphenicol acetyltransferase gene, we showed that the region fromExpand
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Cytokine-induced gene expression at the crossroads of innate immunity, inflammation and fertility: TSG-6 and PTX3/TSG-14.
Two cytokine-inducible gene products, important in inflammation and infection, also play essential roles in female fertility. One of these is the product of tumor necrosis factor (TNF)-stimulatedExpand
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TSG-6: a TNF-, IL-1-, and LPS-inducible secreted glycoprotein associated with arthritis.
TSG-6 (TNF-stimulated gene 6) was originally discovered by differential screening of a cDNA library prepared from TNF-stimulated human diploid FS-4 fibroblasts. We show that the 35-kDa proteinExpand
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Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities.
  • J. Le, J. Vilček
  • Biology, Medicine
  • Laboratory investigation; a journal of technical…
  • 1 March 1987
  • 1,294
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Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guerin and subsequent challenge with lipopolysaccharide
Mice with a targeted disruption of the interferon gamma receptor gene (IFN-gamma R0/0 mice) and control wild-type mice were inoculated with the Bacillus Calmette-Guerin (BCG) strain of MycobacteriumExpand
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