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Determination of stilbenes (trans-astringin, cis- and trans-piceid, and cis- and trans-resveratrol) in Portuguese wines.
TLDR
In a survey of 120 commercial wines from Portugal and France, the highest concentrations of stilbenes were found in red wines, and the glucosides of resveratrol were present in higher concentrations than the free isomers. Expand
Resveratrol exerts its antiproliferative effect on HepG2 hepatocellular carcinoma cells, by inducing cell cycle arrest, and NOS activation.
TLDR
The results indicate that the stilbene inhibits potently cell proliferation, reduces the production of reactive oxygen species and induces apoptosis, through cell cycle arrest in G1 and G2/M phases, and modulates the NO/NOS system, by increasing iNOS and eNOS expression, NOS activity and NO production. Expand
Levels of stilbene oligomers and astilbin in French varietal wines and in grapes during noble rot development.
TLDR
A method for the direct determination of stilbene oligomers (viniferin and pallidol) as well as astilbin in different types of wine using high-performance liquid chromatography with UV detection is described. Expand
Direct liquid chromatographic analysis of resveratrol derivatives and flavanonols in wines with absorbance and fluorescence detection
Abstract Wine contains a large number of polyphenols including stilbenes, flavanols and anthocyanins. Of these, stilbenes have been reported to have potential chemopreventive activities. We describeExpand
The Accumulation of Stilbene Glycosides in Vitis vinifera Cell Suspension Cultures
Suspension cultures of Vitis vinifera grown in an inducive polyphenol synthesis medium accumulated stilbene glycosides. (E)-piceatannol (3,5,3‘,4‘-tetrahydroxystilbene) 3-O-β-glucoside (2) andExpand
Gram-Scale Production and Applications of Optically Pure13C-Labelled (+)-Catechin and (−)-Epicatechin
In this paper gram-scale asymmetric total syntheses of pure (+)-4-[13C]catechin (1) and (−)-4-[13C]epicatechin (2) are described. Labelling was introduced through acylation of a phloroglucinolExpand
STRUCTURAL DETERMINATION OF COLOURLESS AND YELLOW DIMERS RESULTING FROM (+)-CATECHIN COUPLING CATALYSED BY GRAPE POLYPHENOLOXIDASE
Abstract (+)-Catechin oxidation was carried out in aqueous systems using grape polyphenoloxidase as catalyst. Eight fractions corresponding to the major products formed at pH 3 and 6 were purifiedExpand
Polyphenols newly extracted in red wine from southwestern France by centrifugal partition chromatography.
TLDR
Polyphenols from the ethyl acetate extracts of red wine were successfully fractionated using a four-step process, which resulted in the isolation of 22 compounds belonging to different classes of polyphenols (stilbenes, cinnamic acids, flavonoids), five of them reported for the first time. Expand
Quercetin accumulates in nuclear structures and triggers specific gene expression in epithelial cells.
TLDR
Evidence is presented that nonconjugated quercetin enters cells possibly via organic anion transporter polypeptides and quickly accumulates in the nucleus where it concentrates at distinct foci, and that the flavonol modifies the transcription and/or activity of numerous transcription factors. Expand
Resveratrol inhibits the growth and induces the apoptosis of both normal and leukemic hematopoietic cells.
TLDR
Together, the data point to the complexity of RES-mediated signaling pathways and revealed the high anti-proliferative and proapoptotic activities of RES in normal cycling hemopoietic cells. Expand
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