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The genome sequence of Drosophila melanogaster.
TLDR
The nucleotide sequence of nearly all of the approximately 120-megabase euchromatic portion of the Drosophila genome is determined using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Expand
Environmental Genome Shotgun Sequencing of the Sargasso Sea
TLDR
Over 1.2 million previously unknown genes represented in these samples, including more than 782 new rhodopsin-like photoreceptors are identified, suggesting substantial oceanic microbial diversity. Expand
Enzymatic assembly of DNA molecules up to several hundred kilobases
We describe an isothermal, single-reaction method for assembling multiple overlapping DNA molecules by the concerted action of a 5′ exonuclease, a DNA polymerase and a DNA ligase. First we recessedExpand
The Sequence of the Human Genome
TLDR
Comparative genomic analysis indicates vertebrate expansions of genes associated with neuronal function, with tissue-specific developmental regulation, and with the hemostasis and immune systems are indicated. Expand
The complete genome sequence of the gastric pathogen Helicobacter pylori
TLDR
Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification, and consistent with its restricted niche, it has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Expand
Genome sequence of the human malaria parasite Plasmodium falciparum
TLDR
The genome sequence of P. falciparum clone 3D7 is reported, which is the most (A + T)-rich genome sequenced to date and is being exploited in the search for new drugs and vaccines to fight malaria. Expand
DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae
TLDR
The V. cholerae genomic sequence provides a starting point for understanding how a free-living, environmental organism emerged to become a significant human bacterial pathogen. Expand
Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae
TLDR
A motif identified within the signal peptide of proteins is potentially involved in targeting these proteins to the cell surface of low–guanine/cytosine Gram-positive species. Expand
The Minimal Gene Complement of Mycoplasma genitalium
TLDR
Comparison of the Mycoplasma genitalium genome to that of Haemophilus influenzae suggests that differences in genome content are reflected as profound differences in physiology and metabolic capacity between these two organisms. Expand
Complete genome sequence of Neisseria meningitidis serogroup B strain MC58.
TLDR
Neisseria meningitidis contains more genes that undergo phase variation than any pathogen studied to date, a mechanism that controls their expression and contributes to the evasion of the host immune system. Expand
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