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All human Na+-K+-ATPase α-subunit isoforms have a similar affinity for cardiac glycosides
Three α-subunit isoforms of the sodium pump, which is the receptor for cardiac glycosides, are expressed in human heart. The aim of this study was to determine whether these isoforms have distinct ...
nAChRs Mediate Human Embryonic Stem Cell-Derived Endothelial Cells: Proliferation, Apoptosis, and Angiogenesis
This study shows for the first time that short-term systemic administrations of low dose nicotine can improve the survival of transplanted hESC-ECs, and enhance their angiogenic effects in vivo.
All human Na(+)-K(+)-ATPase alpha-subunit isoforms have a similar affinity for cardiac glycosides.
- J. Wang, J. Velotta, A. McDonough, R. Farley
- MedicineAmerican journal of physiology. Cell physiology
Results indicate both that the affinity of all human alpha-subunit isoforms for ouabain is similar and that the increased sensitivity of failing human heart to cardiac glycosides is probably due to a reduction in the number of pumps in the heart rather than to a selective inhibition of a subset of pumps with different affinities for the drugs.
Comparison of Transplantation of Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells in the Infarcted Heart
- K. V. D. van der Bogt, S. Schrepfer, +7 authors Joseph C. Wu
- Biology, MedicineTransplantation
- 15 March 2009
This is the first study comparing the in vivo behavior of both cell types in the infarcted heart, and it is shown that ASC and MSC do not tolerate well in the cardiac environment, resulting in acute donor cell death and a subsequent loss of cardiac function similar to control groups.
The cardiac sodium pump: structure and function
- A. McDonough, J. Velotta, R. Schwinger, K. Philipson, R. Farley
- Chemistry, MedicineBasic Research in Cardiology
The results indicated that the affinity of these human a subunit isoforms for ouabain is indistinguishable, and that changes in sensitivity to cardiac glycosides during heart failure are likely due to a decrease in the total number of pumps rather than a shift in expression to a more sensitive isoform.
Interleukin-17 Accelerates Allograft Rejection by Suppressing Regulatory T Cell Expansion
During heart transplantation, IL-17 is crucial for acceleration of acute rejection;IL-17-deficiency enhances regulatory T cell expansion; and gamma delta T cells rather than CD4+ and CD8+ T cells are a potential source of IL- 17.
A Novel JAK3 Inhibitor, R348, Attenuates Chronic Airway Allograft Rejection
R348 is an effective drug, and it is expected to be introduced into clinical transplant pharmacology soon, because it is well tolerated at up to 40mg/kg, but was toxic at 80 mg/kg.
UT-A Urea Transporter Protein in Heart: Increased Abundance During Uremia, Hypertension, and Heart Failure
Multiple UT-A proteins are detected in rat and human heart; the 56-kDa protein is upregulated in rat heart in uremia or models of hypertension; and the rat results can be extended to human heart, where 56- and 51-k da proteins are increased during heart failure.
Impact of intercostal nerve blocks using liposomal versus standard bupivacaine on length of stay in minimally invasive thoracic surgery patients.
- D. Dominguez, S. Ely, Cynthia Bach, Tina Lee, J. Velotta
- MedicineJournal of thoracic disease
- 11 September 2018
The use of liposomal bupivacaine is associated with decreased LOS in postoperative thoracic surgery patients and earlier return to ambulation, and does not, however, decrease 24-hour postoperative pain scores or opioid usage.
RevaTen platelet-rich plasma improves cardiac function after myocardial injury.
- A. Mishra, J. Velotta, +8 authors M. Fischbein
- MedicineCardiovascular revascularization medicine…
- 1 May 2011
OBJECTIVE Cell therapy is an exciting area of investigation for repair of injured myocardial tissue. Platelet-rich plasma (PRP) is an autologous fractionation of whole blood containing high…