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Criteria for cure of acromegaly: a consensus statement.
This statement summarizes the consensus achieved in discussions to develop a consensus defining the criteria for cure of acromegaly.
Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human.
The pathophysiology of the GHRH somatostatin-GH-IGF-I feedback axis is reviewed and it is proposed that this system is best viewed as a multivalent feedback network that is exquisitely sensitive to an array of neuroregulators and environmental stressors and genetic restraints.
Cluster analysis: a simple, versatile, and robust algorithm for endocrine pulse detection.
This work has formulated a computerized algorithm in which a pulse is defined as a statistically significant increase in a "cluster" of hormone values followed by a statisticallysignificant decrease in a second cluster of values.
Pathophysiology of hypercortisolism in depression
- B. Carroll, F. Cassidy, J. Veldhuis
- Medicine, BiologyActa psychiatrica Scandinavica. Supplementum
- 1 February 2007
Adopting the biomarker strategy, adrenocorticotropin (ACTH) and cortisol dynamics in hypercortisolemic and non‐hypercort isolemic depressed in‐patients, and in normal volunteers are studied.
Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men.
- A. Iranmanesh, G. Lizarralde, J. Veldhuis
- MedicineThe Journal of clinical endocrinology and…
- 1 November 1991
It is concluded that age and relative adiposity are distinct and specific correlates of individual attributes of GH secretion and clearance in men.
Dynamic characteristics of blood glucose time series during the course of critical illness: Effects of intensive insulin therapy and relative association with mortality*
- G. Meyfroidt, D. M. Keenan, Xin Wang, P. Wouters, J. Veldhuis, G. Van den Berghe
- MedicineCritical care medicine
- 1 April 2010
Increased blood glucose amplitude variation and pattern irregularity were associated with mortality, irrespective of blood glucose level and the Leuven intensive insulin therapy strategy increased mean daily &dgr; blood glucose while not affecting standard deviation blood glucose and jack-knifed approximate entropy.
Endocrine control of body composition in infancy, childhood, and puberty.
The present critical review examines hormonal regulation of body composition in infancy, childhood, and puberty using gonadal sex steroids and GH/IGF-I as prime determinants of evolving body composition.
Amplitude modulation of a burstlike mode of cortisol secretion subserves the circadian glucocorticoid rhythm.
- J. Veldhuis, A. Iranmanesh, G. Lizarralde, M. L. Johnson
- BiologyThe American journal of physiology
- 1 July 1989
It is concluded that the nyctohemeral pattern of cortisol variation in vivo can be accounted for by an amplitude-modulated, random burstlike mode of cortisol secretion without the need to postulate a tonic modes of cortisol release.
The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations.
- J. Veldhuis, M. Carlson, M. L. Johnson
- BiologyProceedings of the National Academy of Sciences…
- 1 November 1987
Observed physiological patterns of fluctuating plasma hormone concentrations can be accounted for by distinct, highly delimited, random bursts of hormone release separated by intervals of secretory quiescence.
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults.
- J. Licinio, S. Çağlayan, M. Wong
- Medicine, BiologyProceedings of the National Academy of Sciences…
- 30 March 2004
Leptin replacement therapy in leptin-deficient adults with established morbid obesity results in profound weight loss, increased physical activity, changes in endocrine function and metabolism, including resolution of type 2 diabetes mellitus and hypogonadism, and beneficial effects on ingestive and noningestive behavior.