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Broken Limits to Life Expectancy
The evidence presented in the Policy Forum suggests otherwise, and Mortality experts have repeatedly asserted that life expectancy is close to an ultimate ceiling; these experts have been proven wrong.
The impact of heterogeneity in individual frailty on the dynamics of mortality
Calculations based on Swedish mortality data suggest that standard methods overestimate current life expectancy and potential gains in life expectancy from health and safety interventions, while underestimating rates of individual aging, past progress in reducing mortality, and mortality differentials between pairs of populations.
Ageing populations: the challenges ahead
Biodemography of human ageing
- J. Vaupel
- 24 March 2010
Research by demographers, epidemiologists and other biomedical researchers suggests that further progress is likely to be made in advancing the frontier of survival — and healthy survival — to even greater ages.
Diversity of ageing across the tree of life
Great variation among these species, including increasing, constant, decreasing, humped and bowed trajectories for both long- and short-lived species, challenges theoreticians to develop broader perspectives on the evolution of ageing and empiricists to study the demography of more species.
Slowing of mortality rates at older ages in large medfly cohorts.
The results cast doubt on several central concepts in gerontology and the biology of aging: that senescence can be characterized by an increase in age-specific mortality, that the basic pattern of mortality in nearly all species follows the same unitary pattern at older ages, and that species have absolute life-span limits.
The quest for genetic determinants of human longevity: challenges and insights
Large-scale linkage studies of long-lived families, longitudinal candidate-gene association studies and the development of analytical methods provide the potential for future progress in human studies of longevity.
Demography of genotypes: failure of the limited life-span paradigm in Drosophila melanogaster.
Analysis of large cohorts of ten genotypes of Drosophila melanogaster raised under conditions that favored extended survival has revealed variation between genotypes in both the slope and location of age-specific mortality curves, contrary to the limited life-span paradigm.
The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870–1900
- A. M. Herskind, M. McGue, N. Holm, T. Sørensen, B. Harvald, J. Vaupel
- BiologyHuman Genetics
- 1 March 1996
The nature of genetic influences on longevity is probably non-additive and environmental influences non-shared, and there is no evidence for an impact of shared (family) environment.
Lifespan depends on month of birth
Differences in adult lifespan by month of birth decrease over time and are significantly smaller in more recent cohorts, which benefited from substantial improvements in maternal and infant health.