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Broken Limits to Life Expectancy
Is human life expectancy approaching its limit? Many--including individuals planning their retirement and officials responsible for health and social policy--believe it is, but the evidence presentedExpand
The impact of heterogeneity in individual frailty on the dynamics of mortality
Life table methods are developed for populations whose members differ in their endowment for longevity. Unlike standard methods, which ignore such heterogeneity, these methods use differentExpand
Ageing populations: the challenges ahead
If the pace of increase in life expectancy in developed countries over the past two centuries continues through the 21st century, most babies born since 2000 in France, Germany, Italy, the UK, theExpand
Biodemography of human ageing
  • J. Vaupel
  • Biology, Medicine
  • Nature
  • 24 March 2010
Human senescence has been delayed by a decade. This finding, documented in 1994 and bolstered since, is a fundamental discovery about the biology of human ageing, and one with profound implicationsExpand
Diversity of ageing across the tree of life
Evolution drives, and is driven by, demography. A genotype moulds its phenotype’s age patterns of mortality and fertility in an environment; these two patterns in turn determine the genotype’sExpand
The quest for genetic determinants of human longevity: challenges and insights
Twin studies show that genetic differences account for about a quarter of the variance in adult human lifespan. Common polymorphisms that have a modest effect on lifespan have been identified in oneExpand
Slowing of mortality rates at older ages in large medfly cohorts.
It is generally assumed for most species that mortality rates increase monotonically at advanced ages. Mortality rates were found to level off and decrease at older ages in a population of 1.2Expand
The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870–1900
The aim of this study was to explore, in a large and non-censored twin cohort, the nature (i.e., additive versus non-additive) and magnitude (i.e., heritability) of genetic influences onExpand
Demography of genotypes: failure of the limited life-span paradigm in Drosophila melanogaster.
Experimental systems that are amenable to genetic manipulation can be used to address fundamental questions about genetic and nongenetic determinants of longevity. Analysis of large cohorts of tenExpand
Biodemographic trajectories of longevity.
Old-age survival has increased substantially since 1950. Death rates decelerate with age for insects, worms, and yeast, as well as humans. This evidence of extended postreproductive survival isExpand