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Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex
BACKGROUND The Rho GTPases Rho, Rac, and Cdc42 regulate the organization of the actin cytoskeleton by interacting with multiple, distinct downstream effector proteins. Cdc42 controls the formation ofExpand
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Proteomic analysis of arabidopsis seed germination and priming.
To better understand seed germination, a complex developmental process, we developed a proteome analysis of the model plant Arabidopsis for which complete genome sequence is now available. AmongExpand
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Prefoldin, a Chaperone that Delivers Unfolded Proteins to Cytosolic Chaperonin
We describe the discovery of a heterohexameric chaperone protein, prefoldin, based on its ability to capture unfolded actin. Prefoldin binds specifically to cytosolic chaperonin (c-cpn) and transfersExpand
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Identification by redox proteomics of glutathionylated proteins in oxidatively stressed human T lymphocytes
Formation of mixed disulfides between glutathione and the cysteines of some proteins (glutathionylation) has been suggested as a mechanism through which protein functions can be regulated by theExpand
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The minimum information about a proteomics experiment (MIAPE)
The Human Proteome Organization's Proteomics Standards Initiative develops guidance modules for reporting the use of techniques such as gel electrophoresis and mass spectrometry. Expand
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MARKK, a Ste20‐like kinase, activates the polarity‐inducing kinase MARK/PAR‐1
MARK, a kinase family related to PAR‐1 involved in establishing cell polarity, phosphorylates microtubule‐associated proteins (tau/MAP2/MAP4) at KXGS motifs, causes detachment from microtubules, andExpand
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cAMP-dependent Protein Kinase Phosphorylation of EVL, a Mena/VASP Relative, Regulates Its Interaction with Actin and SH3 Domains*
Proteins of the Ena/VASP family are implicated in processes that require dynamic actin remodeling such as axon guidance and platelet activation. In this work, we explored some of the pathways thatExpand
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At least six different actins are expressed in a higher mammal: an analysis based on the amino acid sequence of the amino-terminal tryptic peptide.
Abstract The protein chemical characterization of the amino-terminal tryptic peptide of actin from different bovine tissues shows that at least six different actin structural genes are expressed inExpand
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Purification of a cortical complex containing two unconventional actins from Acanthamoeba by affinity chromatography on profilin-agarose
We identified four polypeptides of 47, 44, 40, and 35 kD that bind to profilin-Sepharose and elute with high salt. When purified by conventional chromatography using an antibody to the 47-kDExpand
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Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor
The leptin system provides a link between adipose mass and the central nervous system. The appetite suppressing effects of leptin are impaired in most obese patients and some mutant mice strains.Expand
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