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Role of Human Hypoxanthine Guanine Phosphoribosyltransferase in Activation of the Antiviral Agent T-705 (Favipiravir)
TLDR
It is demonstrated that human hypoxanthine guanine phosphoribosyltransferase (HGPRT) converts T-705 into its ribose-5′-monophosphate (RMP) prior to formation of T-707-RTP, a novel antiviral compound with broad activity against influenza virus and diverse RNA viruses.
Nucleoside-catabolizing Enzymes in Mycoplasma-infected Tumor Cell Cultures Compromise the Cytostatic Activity of the Anticancer Drug Gemcitabine*
TLDR
The findings suggest that the presence of mycoplasmas in the tumor microenvironment could be a limiting factor for the anticancer efficiency of dFdC-based chemotherapy.
Improving the metabolic fidelity of cancer models with a physiological cell culture medium
TLDR
A physiological medium improves the metabolic fidelity and biological relevance of in vitro cancer models and reveals that breast cancer spheroids grown in Plasmax approximate the metabolic profile of mammary tumors better.
MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer
TLDR
Critical pieces of the FAO machinery have been identified that have the potential to be targeted for improved treatment of patients with TNBC, especially the claudin-low molecular subtype.
Characterization of pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis: implications for the clinical efficacy of nucleoside analogues.
In the present paper we demonstrate that the cytostatic and antiviral activity of pyrimidine nucleoside analogues is markedly decreased by a Mycoplasma hyorhinis infection and show that the
Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.
TLDR
39 ProTides of the fluorinated pyrimidine FUDR are reported as promising new derivatives, which partially bypass the dependence of the current drugs on active transport and nucleoside kinase-mediated activation and are also resistant to metabolic deactivation by phosphorolytic enzymes.
Increased formate overflow is a hallmark of oxidative cancer
TLDR
It is shown that formate production in murine cancers with high oxidative metabolism exceeds the biosynthetic demand and that high formate levels promotes invasion of cancer cells, a hallmark of oxidative cancers.
Mycoplasmas and cancer: focus on nucleoside metabolism
TLDR
Mycoplasma infection may therefore bias experimental work with NAs, and their presence in the tumor microenvironment could be of significance when optimizing nucleoside-based cancer treatment.
Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics
TLDR
A nucleoside monophosphonate scaffold was designed that is recognized by a variety of polymerases and represents an entirely novel and broad technological platform for the development of specific substrate active- or regulatory-site inhibitors with therapeutic potential.
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