• Publications
  • Influence
Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species.
The proto-oncogene bcl-2 inhibits apoptotic and necrotic neural cell death. Expression of Bcl-2 in the GT1-7 neural cell line prevented death as a result of glutathione depletion. IntracellularExpand
  • 1,685
  • 47
Superoxide Dismutase Activity Is Essential for Stationary Phase Survival in Saccharomyces cerevisiae
Yeast lacking copper-zinc superoxide dismutase (CuZnSOD), manganese superoxide dismutase (SOD), catalase T, or metallothionein were studied using long term stationary phase (10-45 days) as a simpleExpand
  • 451
  • 22
Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis.
Copper-zinc superoxide dismutase (CuZnSOD, SOD1 protein) is an abundant copper- and zinc-containing protein that is present in the cytosol, nucleus, peroxisomes, and mitochondrial intermembrane spaceExpand
  • 472
  • 22
  • PDF
SOD2 functions downstream of Sch9 to extend longevity in yeast.
Signal transduction pathways inactivated during periods of starvation are implicated in the regulation of longevity in organisms ranging from yeast to mammals, but the mechanisms responsible forExpand
  • 308
  • 19
  • PDF
How super is superoxide
  • 1,004
  • 18
Local Nanomechanical Motion of the Cell Wall of Saccharomyces cerevisiae
We demonstrate that the cell wall of living Saccharomyces cerevisiae (baker's yeast) exhibits local temperature-dependent nanomechanical motion at characteristic frequencies. The periodic motions inExpand
  • 317
  • 18
Superoxide Dismutases and Superoxide Reductases
Superoxide, O2•–, is formed in all living organisms that come in contact with air, and, depending upon its biological context, it may act as a signaling agent, a toxic species, or a harmlessExpand
  • 361
  • 16
Initiation and elongation in fibrillation of ALS-linked superoxide dismutase
Familial amyotrophic lateral sclerosis (fALS) caused by mutations in copper–zinc superoxide dismutase (SOD1) is characterized by the presence of SOD1-rich inclusions in spinal cords. SimilarExpand
  • 197
  • 15
  • PDF
ACE1, a copper-dependent transcription factor, activates expression of the yeast copper, zinc superoxide dismutase gene.
Copper, zinc superoxide dismutase (SOD1 gene product) (superoxide:superoxide oxidoreductase, EC is a copper-containing enzyme that functions to prevent oxygen toxicity. In the yeastExpand
  • 188
  • 14
  • PDF
Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis
A subset of individuals with familial amyotrophic lateral sclerosis (FALS) possesses dominantly inherited mutations in the gene that encodes copper-zinc superoxide dismutase (CuZnSOD). A4V and G93A,Expand
  • 728
  • 13