Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs.
Approaches to seizure risk assessment in preclinical drug discovery.
Validation of the use of zebrafish larvae in visual safety assessment.
Cardiotoxicity associated with targeting kinase pathways in cancer.
Cardiotoxicity, also referred to as drug-induced cardiac injury, is an issue associated with the use of some small-molecule kinase inhibitors and antibody-based therapies targeting signaling pathways in cancer and laboratory investigations into the underlying molecular mechanisms of heart toxicity induced by these molecules have identified potentially common themes.
An introduction to QT interval prolongation and non‐clinical approaches to assessing and reducing risk
- C. Pollard, N. Abi Gerges, MH Bridgland‐Taylor, A. Easter, TG Hammond, J. Valentin
- Biology, MedicineBritish Journal of Pharmacology
- 1 January 2010
The hERG and in vivo QT data, combined with the likely indication and the estimated free drug level for efficacy, are put together to assess the risk that the potential drug will prolong QT in man.
I(Ks) restricts excessive beat-to-beat variability of repolarization during beta-adrenergic receptor stimulation.
Evaluation of a convenient method of assessing rodent visual function in safety pharmacology studies: effects of sodium iodate on visual acuity and retinal morphology in albino and pigmented rats and…
On the relationship between block of the cardiac Na+ channel and drug‐induced prolongation of the QRS complex
The safety implications of blocking hNav1.5 channels suggest the need to test for this activity early in drug discovery in order to design out any potential liability.
Nonclinical proarrhythmia models: predicting Torsades de Pointes.