Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs.
- M. Winter, W. Redfern, Amanda J. Hayfield, S. Owen, J. Valentin, T. Hutchinson
- BiologyJournal of pharmacological and toxicological…
- 1 May 2008
Approaches to seizure risk assessment in preclinical drug discovery.
- A. Easter, M. Bell, R. Bialecki
- BiologyDrug Discovery Today
- 1 September 2009
Validation of the use of zebrafish larvae in visual safety assessment.
- F. Richards, W. Alderton, T. Hutchinson
- BiologyJournal of pharmacological and toxicological…
- 1 July 2008
Cardiotoxicity associated with targeting kinase pathways in cancer.
- H. Mellor, Alex R Bell, J. Valentin, R. Roberts
- Biology, ChemistryToxicological Sciences
- 1 March 2011
Cardiotoxicity, also referred to as drug-induced cardiac injury, is an issue associated with the use of some small-molecule kinase inhibitors and antibody-based therapies targeting signaling pathways in cancer and laboratory investigations into the underlying molecular mechanisms of heart toxicity induced by these molecules have identified potentially common themes.
An introduction to QT interval prolongation and non‐clinical approaches to assessing and reducing risk
- C. Pollard, N. Abi Gerges, MH Bridgland‐Taylor, A. Easter, TG Hammond, J. Valentin
- Biology, MedicineBritish Journal of Pharmacology
- 1 January 2010
The hERG and in vivo QT data, combined with the likely indication and the estimated free drug level for efficacy, are put together to assess the risk that the potential drug will prolong QT in man.
I(Ks) restricts excessive beat-to-beat variability of repolarization during beta-adrenergic receptor stimulation.
- Daniel M. Johnson, J. Heijman, P. Volders
- BiologyJournal of Molecular and Cellular Cardiology
- 2010
Evaluation of a convenient method of assessing rodent visual function in safety pharmacology studies: effects of sodium iodate on visual acuity and retinal morphology in albino and pigmented rats and…
- W. Redfern, Sharon Storey, J. S. McKay
- BiologyJournal of pharmacological and toxicological…
- 2011
On the relationship between block of the cardiac Na+ channel and drug‐induced prolongation of the QRS complex
- A. Harmer, J. Valentin, C. Pollard
- Medicine, BiologyBritish Journal of Pharmacology
- 1 September 2011
The safety implications of blocking hNav1.5 channels suggest the need to test for this activity early in drug discovery in order to design out any potential liability.
Nonclinical proarrhythmia models: predicting Torsades de Pointes.
- C. Lawrence, C. Pollard, T. Hammond, J. Valentin
- Biology, MedicineJournal of pharmacological and toxicological…
- 1 July 2005
A framework to assess the translation of safety pharmacology data to humans.
- J. Valentin, R. Bialecki, R. Wallis
- BiologyJournal of pharmacological and toxicological…
- 1 September 2009
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