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Rab11 Family Interacting Protein 2 Associates with Myosin Vb and Regulates Plasma Membrane Recycling*
The ternary association of myosin Vb and Rab11-FIP2 with Rab11a suggests that a multimeric protein complex is involved in vesicle trafficking through plasma membrane recycling systems. Expand
Human antibody response to Clostridium difficile toxin A in relation to clinical course of infection
Data suggest an association between a defective humoral response to toxin A and a more severe form of C. difficile infection and indicate that other host-related factors control the severity of CDAD and remain to be elucidated. Expand
Lung mucosal immunity: immunoglobulin-A revisited.
The role of IgA in the defence of mucosal surfaces has now expanded from a limited role of scavenger of exogenous material to a broader protective function with potential applications in immunotherapy. Expand
IgA subclasses in various secretions and in serum.
Evaluation of monoclonal antibodies with specificity for human IgA, IgA subclasses and allotypes and secretory component. Results of an IUIS/WHO collaborative study.
The IgA- and SC-specific McAbs identified in this international collaborative study have potential as immunochemical reference reagents to identify and quantitate monomeric and polymeric IgA in human serum and secretions. Expand
Ectodomains 3 and 4 of Human Polymeric Immunoglobulin Receptor (hpIgR) Mediate Invasion of Streptococcus pneumoniae into the Epithelium*
The results of SpsA binding to human, mouse, and chimeric SC strongly supported the human specificity of this unique interaction and suggested that binding sites in the third and fourth Ig-like domain of human SC (D3 and D4, respectively) are involved in SPSA-pIgR complex formation. Expand
MAL2, a novel raft protein of the MAL family, is an essential component of the machinery for transcytosis in hepatoma HepG2 cells
The functional characterization of MAL2, a member of the MAL protein family, in polarized HepG2 cells is presented and it is shown that this protein is essential for transcytosis in HepG1 cells. Expand
Stimulation of secretory IgA and secretory component of immunoglobulins in small intestine of rats treated withSaccharomyces boulardii
One of the mechanisms by which S. b.b. exerts its immunoprotective effect in the gastrointestinal tract is a stimulation of the intestinal secretion of s-IgA and of the secretory component of immunoglobulins, which is suggested to be due to an increase in enterocyte turnover rate. Expand
Changes in size, subclass, and metabolic properties of serum immunoglobulin A in liver diseases and in other diseases with high serum immunoglobulin A.
A role for the human liver in selective removal of p-IgA from plasma is supported, but another mechanism than the SC-dependent biliary transport should be considered. Expand
Quantification and distribution of chicken immunoglobulins IgA, IgM and IgG in serum and secretions.
Every external secretion investigated was selectively enriched in IgA, as evidenced by a (IGA secretion)/(IgA serum):(IGG secretion)/ (IgG serum) ratio greater than one. Expand