Functional Living Trileaflet Heart Valves Grown In Vitro
In vitro generation of implantable complete living heart valves based on a biomimetic flow culture system that functioned up to 5 months and resembled normal heart valves in microstructure, mechanical properties, and extracellular matrix formation.
Regeneration and orthotopic transplantation of a bioartificial lung
Creation of a bioartificial lung requires engineering of viable lung architecture enabling ventilation, perfusion and gas exchange, and regenerated lungs into orthotopic position showed in vivo function.
The foundations and challenges of tissue engineering, which applies the principles of biology and engineering to the development of functional substitutes for damaged tissue, are discussed.
Microscale technologies for tissue engineering and biology.
- A. Khademhosseini, R. Langer, J. Borenstein, J. Vacanti
- BiologyProceedings of the National Academy of Sciences…
- 21 February 2006
An overview of the use of microfluidics, surface patterning, and patterned cocultures in regulating various aspects of cellular microenvironment is discussed, as well as the application of these technologies in directing cell fate and elucidating the underlying biology.
Regeneration and Experimental Orthotopic Transplantation of a Bioengineered Kidney
- Jeremy J Song, J. Guyette, S. Gilpin, Gabriel González, J. Vacanti, H. Ott
- Medicine, BiologyNature Network Boston
- 1 March 2013
To regenerate functional tissue, rat kidney scaffolds are seeded with epithelial and endothelial cells and perfused these cell-seeded constructs in a whole-organ bioreactor, resulting in grafts that produced rudimentary urine in vitro when perfused through their intrinsic vascular bed.
A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering.
Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation
Novel approach to fabricate porous sponges of poly(D,L-lactic-co-glycolic acid) without the use of organic solvents.
Preparation and characterization of poly(l-lactic acid) foams
Transplantation of Chondrocytes Utilizing a Polymer‐Cell Construct to Produce Tissue‐Engineered Cartilage in the Shape of a Human Ear
- Yilin Cao, J. Vacanti, K. Paige, J. Upton, C. Vacanti
- Medicine, BiologyPlastic and Reconstructive Surgery
- 1 August 1997
It is demonstrated that polyglycolic acid‐polylactic acid constructs can be fabricated in a very intricate configuration and seeded with chondrocytes to generate new cartilage that would be useful in plastic and reconstructive surgery.