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Functional Living Trileaflet Heart Valves Grown In Vitro
In vitro generation of implantable complete living heart valves based on a biomimetic flow culture system that functioned up to 5 months and resembled normal heart valves in microstructure, mechanical properties, and extracellular matrix formation.
Microscale technologies for tissue engineering and biology.
An overview of the use of microfluidics, surface patterning, and patterned cocultures in regulating various aspects of cellular microenvironment is discussed, as well as the application of these technologies in directing cell fate and elucidating the underlying biology.
Regeneration and orthotopic transplantation of a bioartificial lung
Creation of a bioartificial lung requires engineering of viable lung architecture enabling ventilation, perfusion and gas exchange, and regenerated lungs into orthotopic position showed in vivo function.
Tissue engineering.
The foundations and challenges of tissue engineering, which applies the principles of biology and engineering to the development of functional substitutes for damaged tissue, are discussed.
Regeneration and Experimental Orthotopic Transplantation of a Bioengineered Kidney
To regenerate functional tissue, rat kidney scaffolds are seeded with epithelial and endothelial cells and perfused these cell-seeded constructs in a whole-organ bioreactor, resulting in grafts that produced rudimentary urine in vitro when perfused through their intrinsic vascular bed.
A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering.
Microporous, non-woven poly( epsilon -caprolactone) (PCL) scaffolds made by electrostatic fiber spinning were cultured, expanded and seeded on electrospun PCL scaffolds and suggested as a potential candidate scaffold for bone tissue engineering.
Novel approach to fabricate porous sponges of poly(D,L-lactic-co-glycolic acid) without the use of organic solvents.
A technique to fabricate macroporous sponges from synthetic biodegradable polymers using high pressure carbon dioxide processing at room temperature, which resulted in the nucleation and growth of gas cells within the polymer matrix.
Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation
Tissue engineering is an interdisciplinary field which applies the principles of engineering and the life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function, and has now gained wide attention.
New pulsatile bioreactor for in vitro formation of tissue engineered heart valves.
An in vitro cell culture system that provides physiological pressure and flow of nutrient medium to the developing valve constructs and is anticipated that in vitro physical stress will stimulate the tissue engineered heart valve construct to develop adequate strength prior to a possible implantation.
Preparation and characterization of poly(l-lactic acid) foams
Abstract A particulate-leaching method was developed to prepare highly porous biodegradable polymer membranes. It involves the casting of polymer/salt composite membranes followed by the dissolution