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Effect of intrapulmonary tetrahydrocannabinol administration in humans
TLDR
Very low between-subject variability was observed in THC plasma concentrations, characterising the Volcano® vaporizer as a suitable method for the administration of THC, and the results may be applicable in the development of novel cannabinoid agonists and antagonists, and in studies of the pharmacology and physiology of cannabinoid systems in humans. Expand
Pharmacodynamic and pharmacokinetic effects of TPA023, a GABAA α2,3 subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers
TLDR
The results show that the effect profile of TPA023 differs markedly from that of Lorazepam, at doses that were equipotent with regard to effects on saccadic peak veLocity, and these differences reflect the selectivity of T PA023 for different GABAA receptor subtypes. Expand
Biomarkers for the effects of selective serotonin reuptake inhibitors (SSRIs) in healthy subjects.
TLDR
SSRIs in healthy subjects appear to cause slight stimulating effects after low doses, which tend to diminish with dose, and Amitriptyline generally impaired central nervous system (CNS) functions, which increased with doses. Expand
Biomarkers for the effects of benzodiazepines in healthy volunteers.
TLDR
Subjective and objective measures of alertness were most sensitive to benzodiazepines, and the most consistent effects were observed on saccadic peak velocity (SPV) and visual analogue scores ( VAS) of Alertness, where 100% and 79% of all studies respectively showed statistically significant effects. Expand
Acute psychomotor, memory and subjective effects of MDMA and THC co-administration over time in healthy volunteers
TLDR
Co-administration of THC with MDMA increased desired subjective drug effects and drug strength compared with the MDMA condition, which may explain the widespread use of this combination. Expand
Pharmacodynamic and pharmacokinetic effects of MK-0343, a GABAA α2,3 subtype selective agonist, compared to lorazepam and placebo in healthy male volunteers
TLDR
Although less effect on VAS alertness was expected, diminished effects on memory and postural stability were present and clinical studies in anxiety patients should show whether this dose of MK-0343 is therapeutically effective with a different side-effect profile. Expand
Pharmacokinetic and pharmacodynamic profile of oral and intravenous meta-chlorophenylpiperazine in healthy volunteers.
TLDR
It is doubtful whether mCPP is a useful compound for challenge tests in view of the large pharmacokinetic variability after intravenous and oral administration, and the effects of m CPP are consistent with disinhibition of the central nervous system. Expand
Modelling of the concentration—effect relationship of THC on central nervous system parameters and heart rate — insight into its mechanisms of action and a tool for clinical research and development
TLDR
The relationship between THC and its effects on heart rate, body sway and several visual analogue scales was investigated using pharmacokinetic—pharmacodynamic (PK-PD) modelling, which provided insights useful for the research and development of novel cannabinoids and the physiology and pharmacology of cannabinoid systems. Expand
Inhibition of THC-induced effects on the central nervous system and heart rate by a novel CB1 receptor antagonist AVE1625
TLDR
AVE1625 penetrates the brain and antagonises THC-induced effects with doses at or above 20 mg, and shows a useful method for studying the effects of CB1 antagonists. Expand
The sensitivity of pharmacodynamic tests for the central nervous system effects of drugs on the effects of sleep deprivation
TLDR
It isphasized that reductions in adaptive tracking, saccadic peak velocity and body sway caused by sedative drugs really reflect sedation, and the motivation and alertness necessary for DSST may overcome mild sedation. Expand
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