J. V. van Embden

Publications115
h-index68
Citations19,932
Highly Influential Citations799
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Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology
TLDR
A novel method based on strain-dependent hybridization patterns of in vitro-amplified DNA with multiple spacer oligonucleotides was found to differentiate M. bovis from M. tuberculosis, a distinction which is often difficult to make by traditional methods.
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Strain identification of Mycobacterium tuberculosis by DNA fingerprinting: recommendations for a standardized methodology
TLDR
A standardized technique which exploits variability in both the number and genomic position of IS6110 to generate strain-specific patterns will facilitate investigations into the international transmission of tuberculosis and may identify specific strains with unique properties such as high infectivity, virulence, or drug resistance.
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Comparison of Methods Based on Different Molecular Epidemiological Markers for Typing of Mycobacterium tuberculosis Complex Strains: Interlaboratory Study of Discriminatory Power and Reproducibility
TLDR
Strain differentiation by IS6110 RFLP or mixed-linker PCR are the methods of choice for epidemiological investigations, indicating a clonal population structure of M. tuberculosis strains.
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Predominance of a single genotype of Mycobacterium tuberculosis in countries of east Asia
TLDR
Analysis of the population structure of Mycobacterium tuberculosis strains from the People's Republic of China showed that the vast majority belong to a genetically closely related group, which is designated the "Beijing family" of M. tuberculosis strains, indicating that strains of the Beijing family recently expanded from a single ancestor which had a selective advantage.
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Multilocus Sequence Typing Scheme for Enterococcus faecium
TLDR
The MLST results suggest that epidemic lineages of E. faecium emerged recently worldwide, while genetic variation in both VREF and VSEF was created by longer-term recombination.
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Comparative Genotyping of Campylobacter jejuni by Amplified Fragment Length Polymorphism, Multilocus Sequence Typing, and Short Repeat Sequencing: Strain Diversity, Host Range, and Recombination
TLDR
Typing of Campylobacter strains is useful for identification of outbreaks but is probably not useful for source tracing and global epidemiology because of carriage of strains of multiple types and an extremely high diversity of strains in animals.
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A novel pathogenic taxon of the Mycobacterium tuberculosis complex, Canetti: characterization of an exceptional isolate from Africa.
TLDR
This study supports the idea that the established members within the M. tuberculosis complex and the newly described Canetti grouping should be regarded as a single species, which likely will be designated "M. tuberculosis".
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Spacer oligonucleotide typing of Mycobacterium bovis strains from cattle and other animals: a tool for studying epidemiology of tuberculosis
TLDR
By spoligotyping, isolates from the Spanish wild boar and deer had the same pattern as some bovine isolates, suggesting transmission between these animals and cattle and highlighting the importance of the study of these reservoirs.
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Diagnosis of Mycobacterium microtiInfections among Humans by Using Novel Genetic Markers
TLDR
DNA typing of Mycobacterium microtiisolates from animals in the United Kingdom and The Netherlands diagnosed four human M. microti infections, the first M.microti infections among humans to be reported, suggesting that geographic isolation led to divergent strains in the UK and on the continent.
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Genetic Variation and Evolutionary Origin of the Direct Repeat Locus of Mycobacterium tuberculosis Complex Bacteria
TLDR
The data strongly suggest that the polymorphism in clinical isolates is the result of successive deletions of single discrete DVRs or of multiple contiguous DTVs from a primordial DR region containing many more DVRS than seen in present day isolates and that virtually no scrambling of DVR's took place during evolution.
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