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Drug absorption. I. An in situ rat gut technique yielding realistic absorption rates.
A method is reported for studying gastrointestinal drug absorption from isolated gut segments of the anesthetized rat in situ. The experimental technique is simple and utilizes readily availableExpand
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An in vitro model to simulate some factors involved in the absorption process is described. It consists of a tube containing two aqueous phases separated by an immiscible phase. A rocking apparatusExpand
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Acetaminophen prodrugs. I. Synthesis, physicochemical properties, and analgesic activity.
Carbonate and carboxylic acid ester prodrugs of acetaminophen were prepared. As expected, they had lower water solubilities and higher oil/water partition coefficients than acetaminophen itself. AtExpand
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Maturing of Pharmaceutical Education
In this paper the author recommends that American pharmaceutical education should move rapidly in the direction of a single terminal professional doctor of pharmacy degree for all of its graduates.Expand
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Control of urine pH and its effect on sulfaethidole excretion in humans.
A technique is described whereby urine can be excreted by human subjects, at a pH near 5.0 or 8.0, with a variation of not more than 0.1 or 0.2 pH unit over periods of at least 15 hours. TheExpand
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Drug absorption. 3. Effect of membrane storage on the kinetics of drug absorption.
Monoexponential and biexponential disappearance of drug was observed both from the simulated gut phase of a three-phase in vitro model for drug absorption and from the lumen of an in situ rat gut.Expand
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Enhancement of gastrointestinal absorption of a quaternary ammonium compound by trichloroacetate.
The hypothesis that ion-pair formation and transport across the lipid gastrointestinal barrier is an important mechanism for drug absorption has been examined using a quaternary ammonium compound,Expand
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A simple rocking apparatus has been constructed for routine determination of distribution coefficients. With this apparatus, up to 36 two-phase samples in cylindrical tubes are equilibrated byExpand
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The physics of tablet compression. II. The influence of degree of compression on properties of tablets.
A study has been made of the influence of compressional force employed in tablet compression on the apparent density, porosity, hardness, disintegration time, and average primary particle size ofExpand
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Drug partitioning III. Kinetics of drug transfer in an in vitro model for drug absorption
The kinetics of drug transfer from a buffered aqueous phase (compartment A ) through a lipid phase (compartment B ) to another aqueous buffered phase (compartment C ) are reported. These kinetics areExpand
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