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Multidrug resistance in Aspergillus nidulans involves novel ATP-binding cassette transporters
Two single-copy genes, designated atrA and atrB (ATP-binding cassette transporter A and B), were cloned from the filamentous fungus Aspergillus nidulans and sequenced. Based on the presence ofExpand
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The synthesis of mono- and dihydroxy aromadendrane sesquiterpenes, starting from natural (+)-aromadendrene-III
Abstract The monoalcohols (−)-globulol ( 2 ), (−)-epiglobulol ( 3 ), (−)-ledol ( 4 ), and (+)-viridiflorol ( 5 ) were synthesized from (+)-aromadendrene ( 1 ). The cis-fused alloaromandedrone ( 14 ),Expand
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Variation in sensitivity to fungicides which inhibit ergosterol biosynthesis in wheat powdery mildew
Fungicides which inhibit ergosterol biosynthesis have been in use for control of wheat powdery mildew (Erysiphe graminis f. sp.tritici) in the Netherlands since 1978. Mildew populations were testedExpand
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An energy-dependent efflux mechanism for fenarimol in a wild-type strain and fenarimol-resistant mutants of Aspergillus nidulans
Abstract Uptake of [ 14 C]fenarimol (30 μ M ) by mycelium of wild-type Aspergillus nidulans was characterized by a rapid initial accumulation during the first 10 min of incubation with the fungicideExpand
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Mechanism of resistance to fenarimolin Aspergillus nidulans
Abstract Mycelial uptake of [ 14 C]fenarimol (10 μg/ml) by 20 fenarimol-resistant mutants of Aspergillus nidulans was compared with uptake by wild-type strain 003. Uptake of the fungicide during theExpand
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Accumulation of SBI fungicides in wild-type and fenarimol-resistant isolates of Penicillium italicum
Fenarimol-resistant laboratory isolates of Penicillium italicum exhibit a high degree of cross-resistance to triazoles, a low degree of cross-resistance to imazalil and a low degree ofExpand
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Stepwise development of laboratory resistance to DMI-fungicides in Penicillium italicum
Isolates ofPenicillium italicum with differential levels of resistance to imazalil were obtained via step-wise mass selection of conidia of the fenarimol-resistant isolate E300-3 on imazalilamendedExpand
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Inhibitors of energy-dependent efflux of the fungicide fenarimol byAspergillus nidulans
Abstract Fenarimol is a fungicide classified as a sterol biosynthesis inhibitor (SBI). Its passive influx in mycelium of wild-type and SBI-resistant strains of Aspergillus nidulans is counteracted byExpand
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Isolation and molecular characterisation of the gene encoding eburicol 14α-demethylase (CYP51) fromPenicillium italicum
TheCYP51 gene encoding eburicol 14α-demethylase (P45014DM) was cloned from a genomic library of the filamentous fungal plant pathogenPenicillium italicum, by heterologous hybridisation with theExpand
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