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Genotoxicity of quercetin in cultured mammalian cells.
The naturally occurring flavonol, quercetin, was investigated concerning its ability to induce SCEs and HGPRT-deficient mutants in V79 Chinese hamster cells, and HGPRT- and TK-deficient mutants inExpand
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An alternative approach for the safety evaluation of new and existing chemicals, an exercise in integrated testing.
Various in vitro and in silico methods without animals were applied to 10 substances listed on ELINCS with a complete VIIA base-set available at NOTOX. The hazard assessment for these substances wasExpand
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Aquilide A, a new mutagenic compound isolated from bracken fern (Pteridium aquilinum (L.) Kuhn).
A mutagenic compound, designated aquilide A, was isolated and identified from bracken fern (Pteridium aquilinum (L.) Kuhn). Aquilide A was found to be responsible for greater than 50% of theExpand
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Alternative approaches can greatly reduce the number of fish used for acute toxicity testing.
Acute toxicity tests with algae, daphnids, and fish are required for the classification and environmental risk assessment of chemicals. The degree of risk is determined by the lowest of these acuteExpand
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Absorption of a mutagenic metabolite released from protein-bound residues of furazolidone.
The use of nitrofurans as veterinary drugs has been banned in the EU since 1993 due to doubts on the safety of the protein-bound residues of these drugs in edible products. Following treatment ofExpand
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Continuous intravenous infusion in the unrestrained rat — procedures and results
1 A method of continuous infusion in the unrestrained rat is described, which provides a scientifically accept able and easily maintained rodent model for use in toxicological investigations. 2Expand
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Antimutagenic activity of some naturally occurring compounds towards cigarette-smoke condensate and benzo[a]pyrene in the Salmonella/microsome assay.
Several compounds, occurring in food, were tested for antimutagenic activity towards cigarette-smoke condensate (CSC) and benzo[a]pyrene (BaP). Antimutagenicity was determined in theExpand
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Mutagenicity of extracts of some vegetables commonly consumed in the Netherlands.
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The killifish Nothobranchius rachowi, a new animal in genetic toxicology.
Nothobranchius rachowi, a tropical fish that belongs to the family of the Cyprinodontidae, is introduced as a new animal for genetic toxicological studies. The karyotype of N. rachowi consists of 16Expand
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Lack of activity of the bacterial mutagen emodin in HGPRT and SCE assay with V79 Chinese hamster cells.
Genotoxicity of emodin was studied in the Salmonella/microsome assay, the sister-chromatid exchange (SCE) assay and the hypoxanthine-guanine-phosphoribosyltransferase (HGPRT) forward mutation assayExpand
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