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Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism
IL-13 is strongly implicated in the development of asthma and chronic obstructive polymonary disease (COPD). We previously identified an IL-13 promoter polymorphism (−1055 C to T) that is associatedExpand
Asthmatic airways obstruction assessment based on detailed analysis of respiratory sound spectra
This paper concerns the analysis of adventitious sounds produced by individual asthmatic patients, and relates the sounds to the degree of airways obstruction at the moment of sound recording. Expand
Activated protein C inhibits neutrophil migration in allergic asthma: a randomised trial
Asthma patients show evidence of a procoagulant state in their airways, accompanied by an impaired function of the anticoagulant protein C system. We aimed to study the effect of recombinant humanExpand
Front & Back Matter
LSC 2013 abstract - Identifying a molecular defect in bronchial epithelial cells from 70% of mild asthmatics
Interleukin-17 (IL-17) synergizes with pro-inflammatory stimuli like TNF-α in an exaggerated production of inflammatory mediators by human primary bronchial epithelial cells (PBEC) which relates to aExpand
Genetic regulation of interleukin-13 production
The 5q31-33 region contains a number of genes, including IL-13, that could be involved in the aetiology of allergic asthma. Other genes of interest in this region are the Th2 cytokines IL-4 and IL-5;Expand