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Re Human and Mammalian Toxic Equivalency Factors for Dioxins and Dioxin-Like Compounds: The Who 2005 Re-Evaluation
Re Human and Mammalian Toxic Equivalency Factors for Dioxins and Dioxin-Like Compounds: The Who 2005 Re-Evaluation
Flame Retardants in Placenta and Breast Milk and Cryptorchidism in Newborn Boys
TLDR
Two different proxies were used for prenatal PBDE exposure, and levels in breast milk, but not in placenta, showed an association with congenital cryptorchidism, and these observations are of concern because human exposure to PBDEs is high in some geographic areas. Expand
Improving health through policies that promote active travel: a review of evidence to support integrated health impact assessment.
TLDR
Evaluating impacts of active travel policies is highly complex; however, many associations can be quantified, and identifying health-maximizing policies and conditions requires integrated HIAs. Expand
Non-carcinogenic effects of TCDD in animals
TLDR
Exposure to TCDD and related chemicals leads to a plethora of effects in multiple species, tissues, and stages of development, including effects on the developing immune, nervous, and reproductive systems, which are close to those present in the background human population. Expand
Polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in the general population in Finland.
TLDR
Exposure of Finns has declined over the last 30 years, and a downward gradient was found in the concentrations from the Baltic Sea coast to inland areas in Finland, and this was assessed to be due to consumption of theBalt Sea fish, especially Baltic herring. Expand
State of the art in benefit-risk analysis: food and nutrition.
TLDR
It is concluded that, provided it is clearly explained, benefit-risk assessment is a valuable approach to systematically show current knowledge and its gaps and to transparently provide the best possible science-based answer to complicated questions with a large potential impact on public health. Expand
Reduction potential of urban PM2.5 mortality risk using modern ventilation systems in buildings.
TLDR
The estimated exposure reductions suggest that correctly defined building codes may reduce annual premature mortality by hundreds in Finland and by tens of thousands in the developed world altogether. Expand
Personal NO2 exposures of preschool children in Helsinki.
TLDR
A regression model explained 32% of the personal NO2 exposure variation in winter and 67% in spring and in the absence of personal exposure measurements, both stationary measurements and questionnaire information are useful in estimating variations in personal exposures. Expand
Structure-activity relationships and dose responses of polychlorinated dibenzo-p-dioxins for short-term effects in 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant and -sensitive rat strains.
TLDR
Comparisons of potency and efficacy of PCDDs between L-E and H/W rats imply that relative potency values derived from mortality are not necessarily valid for other endpoints and support previous observations about two different types of AHR-mediated mechanisms. Expand
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on liver phosphoenolpyruvate carboxykinase (PEPCK) activity, glucose homeostasis and plasma amino acid concentrations in the most
TLDR
Comparisons of dose-responses and time-courses of effects of TCDD on the activity of phosphoenolpyruvate carboxykinase (PEPCK) in liver, liver glycogen concentration as well as plasma concentrations of glucose and amino acids in both genders of T CDD-sensitive Long-Evans (L-E) rats and H/Wistar rats suggest that impairment of this pathway contributes to the development of the wasting syndrome. Expand
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