• Publications
  • Influence
Group I Metabotropic Glutamate Receptor NMDA Receptor Coupling and Signaling Cascade Mediate Spinal Dorsal Horn NMDA Receptor 2B Tyrosine Phosphorylation Associated with Inflammatory Hyperalgesia
TLDR
In rats with Freund's adjuvant-induced inflammation, the increased dorsal horn NR2B tyr-P is blocked by group I metabotropic glutamate receptor (mGluR) antagonists and coimmunoprecipitation indicates that Shank, a postsynaptic density protein associated with mGluRs, formed a complex involving PSD-95,NR2B, and Src in the spinal dorsal horn.
Shank Expression Is Sufficient to Induce Functional Dendritic Spine Synapses in Aspiny Neurons
TLDR
It is reported that knock-down of Shank3/prolinerich synapse-associated protein-2 by RNA interference reduces spine density in hippocampal neurons and transgene expression of Shank 3 is sufficient to induce functional dendritic spines in aspiny cerebellar neurons, which strongly suggest that Shank proteins and the associated glutamate receptors participate in a concerted manner to form spines and functional synapses.
Neuronal activity regulates glutamate transporter dynamics in developing astrocytes
TLDR
Findings indicate that neuronal activity influences both the organization of GluTs in developing astrocyte membranes and their position relative to synapses.
Homer-Dependent Cell Surface Expression of Metabotropic Glutamate Receptor Type 5 in Neurons
TLDR
The results indicate that Homer1 proteins regulate synaptic cycling and Ca2+ signaling of mGlu5 receptors, in response to neuronal activity.
...
...