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Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins
Shank, a Novel Family of Postsynaptic Density Proteins that Binds to the NMDA Receptor/PSD-95/GKAP Complex and Cortactin
Homer Binds a Novel Proline-Rich Motif and Links Group 1 Metabotropic Glutamate Receptors with IP3 Receptors
Homer Regulates the Association of Group 1 Metabotropic Glutamate Receptors with Multivalent Complexes of Homer-Related, Synaptic Proteins
Homer: a link between neural activity and glutamate receptor function
Group I Metabotropic Glutamate Receptor NMDA Receptor Coupling and Signaling Cascade Mediate Spinal Dorsal Horn NMDA Receptor 2B Tyrosine Phosphorylation Associated with Inflammatory Hyperalgesia
In rats with Freund's adjuvant-induced inflammation, the increased dorsal horn NR2B tyr-P is blocked by group I metabotropic glutamate receptor (mGluR) antagonists and coimmunoprecipitation indicates that Shank, a postsynaptic density protein associated with mGluRs, formed a complex involving PSD-95,NR2B, and Src in the spinal dorsal horn.
Structure of the Homer EVH1 Domain-Peptide Complex Reveals a New Twist in Polyproline Recognition
Shank Expression Is Sufficient to Induce Functional Dendritic Spine Synapses in Aspiny Neurons
It is reported that knock-down of Shank3/prolinerich synapse-associated protein-2 by RNA interference reduces spine density in hippocampal neurons and transgene expression of Shank 3 is sufficient to induce functional dendritic spines in aspiny cerebellar neurons, which strongly suggest that Shank proteins and the associated glutamate receptors participate in a concerted manner to form spines and functional synapses.
Neuronal activity regulates glutamate transporter dynamics in developing astrocytes
Findings indicate that neuronal activity influences both the organization of GluTs in developing astrocyte membranes and their position relative to synapses.
Homer-Dependent Cell Surface Expression of Metabotropic Glutamate Receptor Type 5 in Neurons
The results indicate that Homer1 proteins regulate synaptic cycling and Ca2+ signaling of mGlu5 receptors, in response to neuronal activity.