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TTLL7 Is a Mammalian β-Tubulin Polyglutamylase Required for Growth of MAP2-positive Neurites*
TLDR
Findings indicate that TTLL7 is a β-tubulin polyglutamylase and is required for the growth of MAP2-positive neurites in PC12 cells.
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Classification of ‘activation’ antibodies against integrin β1 chain
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Amino Acid Transporter ATA2 Is Stored at the trans-Golgi Network and Released by Insulin Stimulus in Adipocytes*
TLDR
The cellular mechanisms that participate in the acute translocation of ATA2 by insulin stimulus in 3T3-L1 adipocytes are described and demonstrate that the ATA 2 storage site is specifically associated with the trans-Golgi network and not with the general endosomal recycling system.
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Optimization of an LNP-mRNA vaccine candidate targeting SARS-CoV-2 receptor-binding domain
In 2020, two mRNA-based vaccines, encoding the full length of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, have been introduced for control of the coronavirus disease…
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R-130823, a novel inhibitor of p38 MAPK, ameliorates hyperalgesia and swelling in arthritis models.
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Involvement of sphingosine-1-phosphate and S1P1 in angiogenesis: analyses using a new S1P1 antagonist of non-sphingosine-1-phosphate analog.
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The 'ligand-induced conformational change' of alpha 5 beta 1 integrin. Relocation of alpha 5 subunit to uncover the beta 1 stalk region.
TLDR
Results revealed that cells treated with EDTA also express AG89 binding sites with the same affinity although the number of binding sites is 4-fold lower, and data suggest that the AG89 epitope is masked by the alpha5 subunit.
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CorrigendumCorrigendum to “Involvement of sphingosine-1-phosphate and S1P1 in angiogenesis: Analyses using a new S1P1 antagonist of non-sphingosine-1-phosphate analog” [Biochem. Pharmacol. 77 (2009)…
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Relocation of α5 subunit to uncover the β1 stalk region
TLDR
Data suggest that the AG89 epitope is masked by the α5 subunit, and that ligand binding and integrin activation may uncover the β1 stalk region by triggering a conformational shift of α5 relative to β1.
49. AAV Vector-Mediated Gene Delivery of Aromatic L-Amino Acid Decarboxylase Restored L-DOPA Efficacy in a Primate Bilateral Model of Parkinson's Disease
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