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Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain
Using the phage P1-derived Cre/loxP recombination system, we have developed a method to create mice in which the deletion (knockout) of virtually any gene of interest is restricted to a subregion orExpand
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The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory
We have produced a mouse strain in which the deletion of the NMDAR1 gene is restricted to the CA1 pyramidal cells of the hippocampus by using a new and general method that allows CA1-restricted geneExpand
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A chemical switch for inhibitor-sensitive alleles of any protein kinase
Protein kinases have proved to be largely resistant to the design of highly specific inhibitors, even with the aid of combinatorial chemistry. The lack of these reagents has complicated efforts toExpand
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Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice
We produced CA1-specific NMDA receptor 1 subunit-knockout (CA1-KO) mice to determine the NMDA receptor dependence of nonspatial memory formation and of experience-induced structural plasticity in theExpand
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Effects of environmental enrichment on gene expression in the brain.
  • C. Rampon, C. Jiang, +5 authors Y. Hu
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 7 November 2000
An enriched environment is known to promote structural changes in the brain and to enhance learning and memory performance in rodents [Hebb, D. O. (1947) Am. Psychol. 2, 306-307]. To betterExpand
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Impaired Hippocampal Representation of Space in CA1-Specific NMDAR1 Knockout Mice
To investigate the role of synaptic plasticity in the place-specific firing of the hippocampus, we have applied multiple electrode recording techniques to freely behaving mice with a CA1 pyramidalExpand
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NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation.
The hippocampal CA1 region is crucial for converting new memories into long-term memories, a process believed to continue for week(s) after initial learning. By developing an inducible, reversible,Expand
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Deficient Neurogenesis in Forebrain-Specific Presenilin-1 Knockout Mice Is Associated with Reduced Clearance of Hippocampal Memory Traces
To examine the in vivo function of presenilin-1 (PS1), we selectively deleted the PS1 gene in excitatory neurons of the adult mouse forebrain. These conditional knockout mice were viable and grewExpand
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Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior.
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is a hallmark of major depressive disorder. A number of studies have shown that this dysregulation is correlated with impaired forebrainExpand
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Differential effects of enrichment on learning and memory function in NR2B transgenic mice
It has been known that environmental enrichment leads to better learning and memory in mice. However, the molecular mechanisms are not known. In this study, we used the 10th-12th of the NR2BExpand
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