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Refinement of Tools for Targeted Gene Expression in Drosophila
A wide variety of biological experiments rely on the ability to express an exogenous gene in a transgenic animal at a defined level and in a spatially and temporally controlled pattern. We describeExpand
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Spatial and temporal patterns of neurogenesis in the central nervous system of Drosophila melanogaster.
Neurogenesis in the ventral CNS of Drosophila was studied using staining with toluidine blue and birth dating of cells monitored by incorporation of bromodeoxyuridine into DNA. The ventral CNS of theExpand
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The Role of the Prothoracic Gland in Determining Critical Weight for Metamorphosis in Drosophila melanogaster
BACKGROUND The timely onset of metamorphosis in holometabolous insects depends on their reaching the appropriate size known as critical weight. Once critical weight is reached, juvenile hormone (JH)Expand
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A multilevel multimodal circuit enhances action selection in Drosophila
We show that combining mechanosensory and nociceptive cues synergistically enhances the selection of the fastest mode of escape locomotion in Drosophila larvae. Expand
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Using translational enhancers to increase transgene expression in Drosophila
The ability to specify the expression levels of exogenous genes inserted in the genomes of transgenic animals is critical for the success of a wide variety of experimental manipulations. ProteinExpand
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The origins of insect metamorphosis
Insect metamorphosis is a fascinating and highly successful biological adaptation, but there is much uncertainty as to how it evolved. Ancestral insect species did not undergo metamorphosis and thereExpand
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Nitric Oxide and Cyclic GMP Regulate Retinal Patterning in the Optic Lobe of Drosophila
The photoreceptors of Drosophila express a nitric oxide-sensitive guanylate cyclase during the first half of metamorphosis, when postsynaptic elements in the optic lobe are being selected. ThroughoutExpand
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The complete connectome of a learning and memory centre in an insect brain
We provide the first complete wiring diagram of a parallel fiber circuit for adaptive behavioral control in the Drosophila larval mushroom body. Expand
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Ecdysone receptor expression in the CNS correlates with stage-specific responses to ecdysteroids during Drosophila and Manduca development.
In insects, the ecdysteroids act to transform the CNS from its larval to its adult form. A key gene in this response is the ecdysone receptor (EcR), which has been shown in Drosophila to code for 3Expand
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Disruption of a Behavioral Sequence by Targeted Death of Peptidergic Neurons in Drosophila
The neuropeptide eclosion hormone (EH) is a key regulator of insect ecdysis. We tested the role of the two EH-producing neurons in Drosophila by using an EH cell-specific enhancer to activate cellExpand
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