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Refinement of Tools for Targeted Gene Expression in Drosophila
The increased strength and reliability of these optimized reagents overcome many of the previous limitations of these methods and will facilitate genetic manipulations of greater complexity and sophistication in Drosophila melanogaster.
Sequential Nuclear Accumulation of the Clock Proteins Period and Timeless in the Pacemaker Neurons of Drosophila melanogaster
Several aspects of PER and TIM expression were not predicted by the current mechanistic model of the circadian clock in Drosophila and are inconsistent with the hypothesis that Per and TIM function as obligate heterodimers.
Local caspase activity directs engulfment of dendrites during pruning
It is shown that the removal of sensory neuron dendrites during pruning in Drosophila melanogaster is directed by local caspase activity, which is confined to the degenerating dendrite of pruning neurons.
Using translational enhancers to increase transgene expression in Drosophila
Several well-characterized sequence elements derived from plant and insect viruses are able to function in Drosophila to increase the apparent translational efficiency of mRNAs by as much as 20-fold, rendering expression levels sufficient for genetic constructs previously requiring multiple copies to be effective in single copy.
A multilevel multimodal circuit enhances action selection in Drosophila
It is shown that combining mechanosensory and nociceptive cues synergistically enhances the selection of the fastest mode of escape locomotion in Drosophila larvae, and proposed that the multilevel multimodal convergence architecture may be a general feature of multisensory circuits enabling complex input–output functions and selective tuning to ecologically relevant combinations of cues.
The origins of insect metamorphosis
The three stages of the ancestral insect species—pronymph, nymph and adult—are proposed to be equivalent to the larva, pupa and adult stages of insects with complete metamorphosis, which has general implications for insect developmental biology.
Drosophila EcR-B ecdysone receptor isoforms are required for larval molting and for neuron remodeling during metamorphosis.
Observations support the hypothesis that different EcR isoforms control cell-type-specific responses during remodeling of the nervous system at metamorphosis.