Establishing a Framework for the Functional Mammary Gland: From Endocrinology to Morphology
- R. Hovey, J. Trott, B. Vonderhaar
- BiologyJournal of mammary gland biology and neoplasia
- 2004
Defining the hormonal control of ductal development should facilitate a better understanding of the mechanisms underlying mammary gland tumorigenesis and provide the opportunity to further delineate the regulation ofductal development.
Grade-Dependent Metabolic Reprogramming in Kidney Cancer Revealed by Combined Proteomics and Metabolomics Analysis.
- Hiromi I Wettersten, A. Hakimi, R. Weiss
- BiologyCancer Research
- 15 June 2015
An extensive analysis of human RCC tissue employing combined grade-dependent proteomics and metabolomics analysis found that the glutamine metabolism pathway acts to inhibit reactive oxygen species, as evidenced by an upregulated glutathione pathway, whereas the β-oxidation pathway is inhibited, leading to increased fatty acylcarnitines.
Alternative splicing to exon 11 of human prolactin receptor gene results in multiple isoforms including a secreted prolactin-binding protein.
- J. Trott, R. Hovey, S. Koduri, B. Vonderhaar
- Biology, MedicineJournal of Molecular Endocrinology
- 1 February 2003
Data indicate the presence of multiple isoforms of the hPRLR that may function to modulate the endocrine and autocrine effects of PRL in normal human tissue and cancer.
Maternal Regulation of Milk Composition, Milk Production, and Pouch Young Development During Lactation in the Tammar Wallaby (Macropus eugenii )1
- J. Trott, K. Simpson, M. Renfree
- Biology, MedicineBiology of Reproduction
- 1 March 2003
It is demonstrated that the lactating tammar wallaby regulates both milk composition and the rate of milk production and that these determine the rates of PY growth and development, irrespective of the age of the PY.
The Tammar Wallaby: A Model to Study Putative Autocrine-Induced Changes in Milk Composition
- K. Nicholas, K. Simpson, Michael Wilson, J. Trott, D. Shaw
- Biology, MedicineJournal of mammary gland biology and neoplasia
- 1 July 1997
This paper explores the possibility that changes in sucking patterns of the young represent the first step in a mechanism to signal the mammary gland for putative autocrine-induced changes in milk composition.
Glutamine Addiction in Kidney Cancer Suppresses Oxidative Stress and Can Be Exploited for Real-Time Imaging.
- Omran Abu Aboud, S. Habib, R. Weiss
- BiologyCancer Research
- 1 December 2017
It is shown here that ccRCC xenograft tumors under the renal capsule exhibit enhanced oxidative stress compared with adjacent normal tissue and the contralateral kidney and the utility of PET to identify and manage patients withccRCC who are likely to respond to glutaminase inhibitors in the clinic is confirmed.
Expression of novel lipocalin-like milk protein gene is developmentally-regulated during lactation in the tammar wallaby, Macropus eugenii.
- J. Trott, Michael Wilson, R. Hovey, D. Shaw, K. Nicholas
- Biology, MedicineGene
- 23 January 2002
Biochemistry of Esterases Associated with Organophosphate Resistance in Lucilia cuprina with Comparisons to Putative Orthologues in Other Diptera
- P. M. Campbell, J. Trott, C. Claudianos, K. Smyth, R. Russell, J. Oakeshott
- BiologyBiochemical Genetics
- 1 February 1997
The correlated changes among the three biochemical and two resistance phenotypes suggest that they are all properties of one gene/enzyme system; three major allelic variants of that system explain OP susceptibility and the two types of OP resistance.
Genomic and phenotypic analyses of six offspring of a genome-edited hornless bull
- A. Young, T. Mansour, Alison L. Van Eenennaam
- Biology, MedicineNature Biotechnology
- 7 October 2019
A genome-edited hornless compound heterozygous dairy bull transmitted this trait to his offspring and inheritance of either allele produced polled calves, and no other unintended genomic alterations were observed.
Diet-induced metabolic change induces estrogen-independent allometric mammary growth
- G. Berryhill, Julia M Gloviczki, R. Hovey
- Biology, MedicineProceedings of the National Academy of Sciences
- 17 September 2012
It is demonstrated that diet-induced metabolic dysregulation, independently of ovarian function, stimulates allometric growth within the mammary glands via an IGF-IR-dependent mechanism.
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