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A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva
Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. We mapped FOP to chromosome 2q23-24 by linkageExpand
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A biodegradable fibrin scaffold for mesenchymal stem cell transplantation.
A potential therapy to enhance healing of bone tissue is to deliver isolated mesenchymal stem cells (MSCs) to the site of a lesion to promote bone formation. A key issue within this technology is theExpand
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Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy.
The bisphosphonates (BPs) are well established as the treatments of choice for disorders of excessive bone resorption, including Paget's disease of bone, myeloma and bone metastases, andExpand
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The localization of androgen receptors in human bone.
Androgens have important effects on the human skeleton, and deficiency has been associated with bone loss in both males and females. The skeletal actions of androgens may be mediated directly via theExpand
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A review on macrophage responses to biomaterials.
Macrophages are the dominant infiltrating cells that respond rapidly to biomaterial implantation in soft and hard tissues. These cells and their fused morphologic variants, multinucleated giant cellsExpand
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Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva*
Background: Mutations in the ALK2 kinase cause extraskeletal bone formation. Results: We solved the structure of ALK2 in complex with the inhibitor FKBP12. Conclusion: Disease mutations breakExpand
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Modelling nutrient transport in hollow fibre membrane bioreactors for growing three-dimensional bone tissue
Recent experimental studies suggest that hollow fibre membrane bioreactors (HFMBs) may be used to grow three-dimensional (3D) bone tissue, which may then be implanted into patients to repair skeletalExpand
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The relationship between the chemistry and biological activity of the bisphosphonates.
The ability of bisphosphonates ((HO)(2)P(O)CR(1)R(2)P(O)(OH)(2)) to inhibit bone resorption has been known since the 1960s, but it is only recently that a detailed molecular understanding of theExpand
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A New Class of Small Molecule Inhibitor of BMP Signaling
Growth factor signaling pathways are tightly regulated by phosphorylation and include many important kinase targets of interest for drug discovery. Small molecule inhibitors of the bone morphogeneticExpand
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The effects of dexamethasone and 1,25-dihydroxyvitamin D3 on osteogenic differentiation of human marrow stromal cells in vitro.
Effects of dexamethasone and 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] were studied in cultures of adult human marrow stromal cells. In primary culture, dexamethasone (10(-8) M) increased the number ofExpand
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